6533b86dfe1ef96bd12ca197
RESEARCH PRODUCT
A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s disease
Peter KraftAdriana IglesiasSteffen UebeAlberta A H J ThiadensJessica N. Cooke BaileyPaul MitchellOlusola OlawoyeMichele RamsayCaroline C.w. KlaverCaroline C.w. KlaverEranga N. VithanaAyub QassimMark James SimcoePirro G. HysiXin WangAngela J. CreeJuha KarjalainenJuha KarjalainenJuha KarjalainenRené HöhnCornelia M. Van DuijnAndrew J. LoteryVeronique VitartAnthony P KhawajaAnthony P KhawajaTerri L. YoungJames E. MorganJames E. MorganUk Biobank EyeYukihiro ShigaOwen M. SiggsYukihide MomozawaYukihide MomozawaStephen AkafoPuya GharahkhaniRobert P. IgoMasato AkiamaGen TamiyaSarah A. PendergrassNavya Shilpa JosyulaChris HammondDavid A. MackeyFinngen StudyChiea Chuen KhorChiea Chuen KhorChiea Chuen KhorFrancesca PasuttoEwan BirneyPieter W.m. BonnemaijerAarno PalotieSusan E. WilliamsJohn RouhanaNishani AmersinghePeng T. KhawStuart MacgregorChing-yu ChengYoichito KamataniCalvin Chi Pui PangXikun HanAlex W. HewittAlex W. HewittLouis R. PasqualeJae Hee KangEric JorgensonRonald B. MellesMichael HauserLi Jia ChenJonathan HainesMasayuki YamamotoAlicia PoplawskiAyellet V. SegrèJue-sheng OngKazuki HashimotoHélène ChoquetHannah CurrantJamie E. CraigRobert LubenAdam AutonTin AungPaul J. FosterPaul J. FosterToru NakazawaNicholas G. StrouthidisMichiaki KuboK. Saidas NairJaney L. WiggsAdeyinka O. Ashayesubject
Genetics0303 health sciencesgenetic structuresOpen angle glaucomaGlaucomaGenome-wide association studyDiseaseBiologymedicine.diseaseeye diseases3. Good health03 medical and health sciences0302 clinical medicineMeta-analysismedicinesense organsGene030217 neurology & neurosurgery030304 developmental biologyGenetic associationdescription
AbstractWe conducted a large multi-ethnic meta-analysis of genome-wide association studies for primary open-angle glaucoma (POAG) on a total of 34,179 cases vs 349,321 controls, and identified 127 independent risk loci, almost doubling the number of known loci for POAG. The majority of loci have broadly consistent effect across European, Asian and African ancestries. We identify a link, both genome-wide and at specific loci, between POAG and Alzheimer’s disease. Gene expression data and bioinformatic functional analyses provide further support for the functional relevance of the POAG risk genes. Several drug compounds target these risk genes and may be potential candidates for developing novel POAG treatments.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-02-03 |