HLA class I antigen abnormalities and immune escape by malignant cells

Abbreviations used in this paper: APM, antigen processing machinery; β2m,β2 microglobulin; bp, base pair; CTL, cytotoxic T lymphocytes; ER, endoplasmic reticulum; HC, heavy chain; HNSCC, head and neck squamous cell carcinoma; IFN, interferon; IL, interleukin; KIR, killing inhibitory receptors; LMP, low molecular weight proteins; LOH, loss of heterozygosity; mAb, monoclonal antibody; MHC, major histocompatibility complex; NK, natural killer; PA, proteasome activator; PCR, polymerase chain reaction; RCC, renal cell carcinoma; SCLC, small cell-lung carcinoma; TAA, tumor-associated antigens; TAP, transporter associated with antigen processing; TCR, T cell receptor; TNF, tumor necrosis factor; w…