0000000000766183

AUTHOR

Thierry Pédron

showing 1 related works from this author

Study of the cwaRS-ldcA Operon Coding a Two-Component System and a Putative L,D-Carboxypeptidase in Lactobacillus paracasei

2020

International audience; The cell surface is the primary recognition site between the bacterium and the host. An operon of three genes, LSEI_0219 (cwaR), LSEI_0220 (cwaS), and LSEI_0221 (ldcA), has been previously identified as required for the establishment of Lactobacillus paracasei in the gut. The genes cwaR and cwaS encode a predicted two-component system (TCS) and ldcA a predicted D-alanyl-D-alanine carboxypeptidase which is a peptidoglycan (PG) biosynthesis enzyme. We explored the functionality and the physiological role of these three genes, particularly their impact on the bacterial cell wall architecture and on the bacterial adaptation to environmental perturbations in the gut. The …

Microbiology (medical)host-microbe interactionOperonAntimicrobial peptidesMutantlcsh:QR1-502peptidoglycanMicrobiologyhost–microbe interactionlcsh:Microbiology03 medical and health scienceschemistry.chemical_compoundantimicrobial peptides[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyGene030304 developmental biologyRegulation of gene expression0303 health sciencesbiology030306 microbiologyChemistryCarboxypeptidase[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyTwo-component regulatory systemcarboxypeptidaselactic acid bacteriaBiochemistrytwo-component systembiology.proteinPeptidoglycan[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriologygene regulation
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