0000000000766454
AUTHOR
Valentin Ivanov
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
BACKGROUND: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated.METHODS: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population …
Interdisciplinary design methodology for systems of mechatronic systems focus on highly dynamic environmental applications
This paper discusses a series of research challenges in the design of systems of mechatronic systems. A focus is given to environmental mechatronic applications within the chain “Renewable energy production — Smart grids — Electric vehicles”. For the considered mechatronic systems, the main design targets are formulated, the relations to state and parameter estimation, disturbance observation and rejection as well as control algorithms are highlighted. Finally, the study introduces an interdisciplinary design approach based on the intersectoral transfer of knowledge and collaborative experimental activities.