0000000000770106

AUTHOR

Lisandro J. Giovanetti

showing 2 related works from this author

Ag2 and Ag3 clusters: synthesis, characterization, and interaction with DNA.

2015

Subnanometric samples, containing exclusively Ag2 and Ag3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag3 clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag3 clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine. Fil: Buceta, David. Universidad de Santiago de Compostela; España Fil: Busto, Natalia. Unive…

SilverStereochemistryFísico-Química Ciencia de los Polímeros ElectroquímicaIntercalation (chemistry)electrochemical synthesiElectrochemistryCatalysisCatalysiscluster compoundchemistry.chemical_compoundintercalationElectrochemistryProflavineDNA synthesisChemistryChemistry (all)Ciencias QuímicasGeneral ChemistryGeneral MedicineDNAXANESXANESCharacterization (materials science)CrystallographyOrders of magnitude (time)BiochemistrySettore CHIM/03 - Chimica Generale E InorganicaEthidium bromideCLUSTERSKINETIC CONTROLCIENCIAS NATURALES Y EXACTASDNAAngewandte Chemie (International ed. in English)
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Silver Clusters of Five Atoms as Highly Selective Antitumoral Agents Through Irreversible Oxidation of Thiols

2022

Low atomicity clusters present properties dependent on the size, due to the quantum confinement, with well-defined electronic structures and high stability. Here it is shown that Ag5 clusters catalyze the complete oxidation of sulfur to S+6. Ag5 catalytic activity increases with different oxidant species in the order O2 ≪ H2O2 < OH•. Selective oxidation of thiols on the cysteine residues of glutathione and thioredoxin is the primary mechanism human cells have to maintain redox homeostasis. Contingent upon oxidant concentration, Ag5 catalyzes the irreversible oxidation of glutathione and thioredoxin, triggering apoptosis. Modification of the intracellular environment to a more oxidized state…

Cancer therapycatalysissilver clusterssulfur oxidationCondensed Matter PhysicsCatalysisSulfur oxidationElectronic Optical and Magnetic MaterialsBiomaterialsLow atomicity clustersSettore CHIM/03 - Chimica Generale E InorganicaElectrochemistrycancer therapylow atomicity clustersSilver clusters
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