0000000000771645
AUTHOR
Francesco Marcucci
Safety of sublingual immunotherapy started during the pollen season
Sublingual immunotherapy (SLIT) is safer than subcutaneous immunotherapy (SCIT) and this has lead to the reconsideration of the use of ultra-rush schedules for SLIT. The aim of this study was to assess the safety of ultra-rush SLIT in pollen-allergic children according to different timing of administration in relation to the pollen season.In total, 34 children with pollen-induced rhinitis and 36 with pollen-induced asthma and rhinitis, were enrolled and assigned to three study groups: group 1 (n = 17 patients): conventional pre-seasonal-SLIT treatment; group 2 (n = 23 patients), seasonal SLIT ended before the pollen seasonal peak; group 3 (n = 30 patients), SLIT began after the pollen seaso…
Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years
Background The minimum age to start specific immunotherapy with inhalant allergens in children has not been clearly established, and position papers discourage its use in children younger than 5 years. Objective To assess the safety of high-dose sublingual-swallow immunotherapy (SLIT) in a group of children younger than 5 years. Methods Sixty-five children (51 boys and 14 girls; age range, 38-80 months; mean ± SD age, 60 ± 10 years; median age, 60 months) were included in this observational study. They were treated with SLIT with a build-up phase of 11 days, culminating in a top dose of 300 IR (index of reactivity) and a maintenance phase of 300 IR 3 times a week. The allergens used were ho…
Effectiveness of high dose sublingual immunotherapy to induce a stepdown of seasonal asthma: a pilot study
There is ample evidence to support the efficacy of sublingual immunotherapy (SLIT) on allergic rhinitis, while there is less solid data regarding asthma. We evaluated the effects of a high dose birch SLIT on birch-induced rhinitis and asthma in a controlled study.This double-blind, placebo-controlled, randomised, single centre trial on SLIT with birch pollen allergen extract (Stallergenes, Antony, France) included 24 patients presenting severe rhinitis and slight to moderate asthma, 14 actively and 10 placebo treated. SLIT was performed by a pre-coseasonal protocol, and was repeated for 2 years. The study plan included a selection visit, a visit at the start of the first and the second trea…
Bone metabolism in children with asthma treated with nebulized flunisolide: a multicenter italian study
Abstract This multicenter, parallel-group, open-label, randomized study was conducted in prepubertal children with mild asthma to investigate the efficacy and influence on bone and collagen turnover of a daily regimen of flunisolide 1200 μg alone (group A, n=14), flunisolide 600 μg in combination with sodium cromoglycate (SCG) 60 mg (group B, n=15), or SCG 60 mg alone (group C, n=15) for 4 months. All medications were administered by means of a jet nebulizer using a mouthpiece. Serum osteocalcin (OC), bone alkaline phosphate (B-ALP), and procollagen type I carboxyterminal propeptide (PICP) were measured as markers of bone formation, and type I collagen telopeptide (ICTP) was measured as a m…