0000000000773496

AUTHOR

U Schmitt

showing 2 related works from this author

Einfluss von THC auf die Glukoseaufnahme und den zellulären Energiestatus im Rattenhirn und auf die Impulskontrolle

2021

59. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin
researchProduct

Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.

1999

The behavioural consequences of inhibition of gamma-aminobutyric acid (GABA) uptake were studied. Two GABA uptake inhibitors, tiagabine and SKF 89976-A, were administered to rats, and behaviour was analysed 30 min later in a standard open field, an enriched open field, and an elevated plus-maze. Eight groups of animals received either saline (0.9%), tiagabine, or SKF 89976-A. At a dose of 18.5 mg/kg, tiagabine, an established antiseizure drug, impaired motor coordination, enhanced exploratory activity and reduced anxiety related behaviour. SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might be a pharmacological strate…

GABA Plasma Membrane Transport ProteinsMaleElevated plus mazeGABA Plasma Membrane Transport ProteinsTiagabineGABA AgentsNipecotic AcidsOrganic Anion TransportersPharmacologyAnxietyEnvironmentMotor Activitygamma-Aminobutyric acidOpen fieldmedicineGABA transporterAnimalsTiagabineGABA Agonistsgamma-Aminobutyric AcidPharmacologybiologyBehavior AnimalDose-Response Relationship DrugChemistryMembrane ProteinsMembrane Transport ProteinsRatsPsychiatry and Mental healthGABA Agentsnervous systembiology.proteinExploratory BehaviorGABA Uptake InhibitorsAnticonvulsantsCarrier Proteinsmedicine.drugBehavioural pharmacology
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