6533b86dfe1ef96bd12ca939
RESEARCH PRODUCT
Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.
C HiemkeU Schmittsubject
GABA Plasma Membrane Transport ProteinsMaleElevated plus mazeGABA Plasma Membrane Transport ProteinsTiagabineGABA AgentsNipecotic AcidsOrganic Anion TransportersPharmacologyAnxietyEnvironmentMotor Activitygamma-Aminobutyric acidOpen fieldmedicineGABA transporterAnimalsTiagabineGABA Agonistsgamma-Aminobutyric AcidPharmacologybiologyBehavior AnimalDose-Response Relationship DrugChemistryMembrane ProteinsMembrane Transport ProteinsRatsPsychiatry and Mental healthGABA Agentsnervous systembiology.proteinExploratory BehaviorGABA Uptake InhibitorsAnticonvulsantsCarrier Proteinsmedicine.drugdescription
The behavioural consequences of inhibition of gamma-aminobutyric acid (GABA) uptake were studied. Two GABA uptake inhibitors, tiagabine and SKF 89976-A, were administered to rats, and behaviour was analysed 30 min later in a standard open field, an enriched open field, and an elevated plus-maze. Eight groups of animals received either saline (0.9%), tiagabine, or SKF 89976-A. At a dose of 18.5 mg/kg, tiagabine, an established antiseizure drug, impaired motor coordination, enhanced exploratory activity and reduced anxiety related behaviour. SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might be a pharmacological strategy to treat not only epilepsy, but also anxiety disorders.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-03-01 | Behavioural pharmacology |