0000000000773920

AUTHOR

Markus Bettendorf

showing 2 related works from this author

MRI findings and genotype analysis in patients with childhood onset growth hormone deficiency--correlation with severity of hypopituitarism.

2007

Aim: To evaluate the relationship between pituitary size, PIT1 and PROP1 genotype, and the severity of childhood onset growth hormone deficiency (coGHD). Patients: Forty-four patients with coGHD (34 M; 9.7 ± 4.1 years): severe isolated (SI) GHD (n = 14); partial isolated (PI) GHD (n = 13); multiple pituitary hormone deficiencies (MPHD) (n=17). Results: Pituitary abnormalities were found in 7/14 patients with SIGHD (50%), 16/17 patients with MPHD (94.1%), and no patient with PIGHD. Mean pituitary height (PHT SDS) was significantly lower in MPHD than in SIGHD and PIGHD. Pituitary height SDS and pituitary volume (PV) SDS correlated with IGF-I SDS and stimulated GH peaks in the SIGHD and MPHD g…

Malemedicine.medical_specialtyAdolescentGenotypeEndocrinology Diabetes and MetabolismGenotype AnalysisHypopituitarismHypopituitarismGrowth hormone deficiencyCorrelationEndocrinologyInternal medicineAge Determination by SkeletonGenotypemedicineHumansIn patientAge of OnsetChildDwarfism PituitaryRetrospective StudiesHomeodomain Proteinsbusiness.industrymedicine.diseaseMagnetic Resonance ImagingBody HeightEndocrinologyChild PreschoolPituitary GlandPediatrics Perinatology and Child HealthPituitary hormonesDisease ProgressionFemalebusinessTranscription Factor Pit-1Mri findingsJournal of pediatric endocrinologymetabolism : JPEM
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Krankheiten der Schilddrüse

2020

Schilddrusenhormone spielen nicht nur im Energiestoffwechsel eine zentrale Rolle. Sie sind vor allem fur das normale Wachstum und die normale korperliche und geistige Entwicklung des Kindes unentbehrlich. Ihre Wirkung wird durch spezifische Schilddrusenhormonrezeptoren vermittelt die sich im Zellkern befinden und die Transkription der vom Schilddrusenhormon abhangigen Gene regulieren. Unter Kontrolle der hypothalamisch-hypophysaren-thyreoidalen Achse besteht normalerweise eine euthyreote Stoffwechselsituation. Storungen dieses Regelkreises konnen die optimale Entwicklung des Kindes gefahrden und sollten deswegen fruhzeitig erkannt und behandelt werden. Meist handelt es sich um eine Uber- od…

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