0000000000775061

AUTHOR

S Maiberger

showing 2 related works from this author

Evidence against a key role for transforming growth factor-beta1 in cytomegalovirus-induced bone marrow aplasia.

1998

During immunodeficiency after sublethal haematoablative treatment, cytomegalovirus (CMV) infection interferes with haematopoietic reconstitution and can cause lethal bone marrow (BM) aplasia. The in vivo model of murine CMV infection has identified the BM stroma as the principal target site of CMV in the haematopoietic cord. The infected cell type is the reticular stromal cell which forms the stromal network and produces essential haemopoietins, such as stem-cell factor (SCF). The expression of SCF was found to be reduced in the infected stroma, but the stromal network was not disrupted and the number of infected stromal cells was too low to explain the functional deficiency. These facts ca…

Stromal cellmedicine.medical_treatmentCytomegalovirusGene ExpressionBone Marrow CellsBone Marrow AplasiaCD8-Positive T-LymphocytesKidneyVirus ReplicationMiceTransforming Growth Factor betaVirologymedicineAnimalsCytotoxic T cellBone Marrow DiseasesBone Marrow TransplantationMice Inbred BALB CbiologyTransforming growth factor betaVirologyHematopoiesisHaematopoiesisCytokinemedicine.anatomical_structureLiverCytomegalovirus Infectionsbiology.proteinFemaleImmunotherapyBone marrowStromal CellsTransforming growth factorJournal of General Virology
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Bone marrow failure by cytomegalovirus is associated with an in vivo deficiency in the expression of essential stromal hemopoietin genes.

1997

Bone marrow (BM) failure associated with cytomegalovirus (CMV) infection is a feared complication after clinical BM transplantation. Experiments in long-term BM cultures have indicated that BM stromal cells (BMSC) are targets of productive CMV infection, but an in situ infection of BM stroma remained to be documented, and the pathomechanism is open to question. Here we describe a murine in vivo model of lethal CMV aplastic anemia (CMV-AA). The reconstitution of hematopoietic progenitor cells expressing stem cell factor (SCF) receptor was found to be defective in CMV-AA. While murine CMV replication in permissive parenchymal tissues is cytolytic, the hematopoietic cord was found to be a site…

MaleStromal cellImmunologyGene ExpressionStem cell factorBiologyHematopoietic Cell Growth FactorsMicrobiologyMiceBone MarrowVirologyGranulocyte Colony-Stimulating FactormedicineAnimalsRNA MessengerAplastic anemiaMice Inbred BALB CStem Cell FactorInterleukin-6Hematopoietic Cell Growth FactorsBone marrow failureAnemia Aplasticmedicine.diseaseHematopoiesisTransplantationHaematopoiesisProto-Oncogene Proteins c-kitmedicine.anatomical_structureInsect ScienceImmunologyCytomegalovirus InfectionsFemaleBone marrowResearch Article
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