Author: Johanna Mrena

0000000000775564

AUTHOR

Johanna Mrena

Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer

Abstract Background Immune response against cancer has prognostic impact but its role in gastric cancer is poorly known. The aim of the study was to assess the prognostic significance of immune cell score (CD3+, CD8+), tumour immune escape (PD-L1, PD-1) and immune tolerance (Clever-1). Methods After exclusion of Epstein-Barr virus positive (n = 4) and microsatellite instable (n = 6) tumours, the study included 122 patients with GC undergoing D2 gastrectomy. CD3+ and CD8+ based ICS, PD-L1, PD-1 and Clever-1 expressions were evaluated. Differences in survival were examined using Cox regression adjusted for confounders. The primary outcome was 5-year survival. Results The 5-year overall surviv…

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Ruoansulatuskanavan tähystysten monimuoto-opetus kirurgian ja sisätautien runkokoulutuksessa

Lähtökohdat: Keski-Suomen keskussairaalassa on vuodesta 2011 järjestetty gastroenterologian monimuotoista perehdytys-koulutusta, joka on pakollinen kaikille kirurgian ja sisätautien alojen runkokoulutettaville. Tavoitteena on antaa kokonaiskuva tähystysten merkityksestä diagnostiikassa, tähystyksen aiheista, yleisimmistä endoskooppisista löydöksistä ja toimenpiteistä sekä niiden seurannasta. Noin 3 kuukauden koulutus sisältää itsenäistä opiskelua verkkomateriaaleista, oppimistehtävän ja harjoittelua tietokonepohjaisella tähystyssimulaattorilla. Menetelmät: Vuonna 2011 koulutuksen aloitti 20 lääkäriä, joista yhdeksällä ei ollut aiempaa kokemusta simulaattorilla harjoittelusta. Osallistujista…

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Immune cell score, PD-L1 expression and prognosis in esophageal cancer.

Esophageal cancer (EC) is the ninth most common cancer worldwide and the sixth leading cause of cancer death [1]. Despite improvements in the treatment of EC, the general outcome remains poor [2–4]...

research product

Immune cell score, PD-L1 expression and prognosis in esophageal cancer

Immune cell score, PD-L1 expression and prognosis in esophageal cancer

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