0000000000777901
AUTHOR
Wolfgang Reith
Effects of a Feedback-Demanding Stroke Clock on Acute Stroke Management: A Randomized Study.
Background and Purpose: This randomized study aimed to evaluate whether the use of a stroke clock demanding active feedback from the stroke physician accelerates acute stroke management. Methods: For this randomized controlled study, a large-display alarm clock was installed in the computed tomography room, where admission, diagnostic work-up, and intravenous thrombolysis occurred. Alarms were set at the following target times after admission: (1) 15 minutes (neurological examination completed); (2) 25 minutes (computed tomography scanning and international normalized ratio determination by point-of-care laboratory completed); and (3) 30 minutes (intravenous thrombolysis started). The resp…
Notiz über die thermische Umlagerung vonO-Benzoyl-N-methyl-N-[ 2-( methylthio)phenyll hydroxylamin
Die thermische Umlagerung von O-Benzoyl-N-methyl-N-[2-(methylthio)phenyl] hydroxylamin (1) in Benzoesaure-[2-(methylaminocarbonyl)phenylthiomethylester] (2) wird beschrieben. Note on the Thermal Rearrangement of O-Benzoyl-N-methyl-N-[2-( methylthio)phenyl]hydroxylamine The thermal rearrangement of O-benzoyl-N-methyl-N-[2-(methylthio)phenyl] hydroxylamine (1) to 2-(methylaminocarbonyl)phenylthiomethyl benzoate (2) is described.
Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PET
Abstract Transcranial ultrasound (TCS) has been shown to reveal hyperechogenicity of the substantia nigra (SN) in Parkinsonian patients and in about 10% of healthy controls. It is hypothesized that SN hyperechogenicity in healthy subjects is a vulnerability marker for idiopathic Parkinson's disease (IPD). Although there is strong evidence that the echomarker results from increased local iron content, the exact pathophysiological mechanisms remain incompletely understood. Thus, prognostic impact can only be estimated. We examined 14 subjects with SN hyperechogenicity (SN+) (7 IPD patients and 7 controls) and 7 healthy controls without the echomarker (SN−) by a magnetic resonance imaging meth…