0000000000786497
AUTHOR
Luis Martínez-dolz
Clinical Predictors of Immunotolerance in Heart Transplantation
Abstract Background and Aim The drugs routinely administered to prevent rejection often cause lethal side effects. Tolerant patients, therefore, should be identified to minimize these problems. The aim of this analysis was to identify clinical variables that may be associated with tolerance. Methods We recruited 522 heart transplants (HT), excluding combined procedures, retransplantations, pediatric recipients, and subjects who died in the first year to obtain a cohort of 375 patients. Two groups were distinguished by the presence of echocardiographic, clinical, or pathological evidence of rejection in the first year (15 echocardiograms and 10 protocol biopsies per patient); 99 tolerant pat…
Epidemiological Study of Tricuspid Regurgitation After Cardiac Transplantation. Does it Influence Survival?
Background: Tricuspid valve disease is the most frequent valvulopathy after heart transplantation (HTx). Evidence for the negative effect of post-transplant tricuspid regurgitation (TR) on survival is contradictory. The aim of this study was to analyze the causes of post-transplant TR and its effect on overall mortality.Methods: This is a retrospective observational study of all transplants performed in two Spanish centers (1009 patients) between 2000 and 2019. Of the total number of patients, 809 had no TR or mild TR and 200 had moderate or severe TR. The etiology of TR was analyzed in all cases.Results: The prevalence of moderate and severe TR was 19.8%. The risk of mortality was greater …
Cambios en la expresión de adrenoceptores y GRK en pacientes con insuficiencia pulmonar valvular crónica
Resumen Introduccion y objetivos La insuficiencia pulmonar (IP) es una complicacion frecuente tras la intervencion de cardiopatias congenitas. La expresion en leucocitos mononucleares circulantes (LMC) de los adrenoceptores (β1 y β2) y de las cinasas (GRK2, GRK3 y GRK5) refleja los cambios neurohumorales que se producen en la insuficiencia cardiaca (IC). El objetivo principal es describir la expresion genica de dichas moleculas en LMC de pacientes con IP grave. Metodos Estudio prospectivo que analizo la expresion de las moleculas descritas en LMC de pacientes con IP grave en comparacion con controles sanos y pacientes con IC avanzada. Resultados Se estudio a 35 pacientes con IP grave, 22 co…