0000000000787409
AUTHOR
Silvana P. Barros
Effects of simultaneous nicotine and alcohol use in periodontitis progression in rats: A histomorphometric study
The aim of this study was to evaluate the effects of alcohol and nicotine, when used alone or simulta - neously, on the alveolar bone loss area resulting from ligature-induced periodontitis in rats. Study design: Forty adult male rats received a cotton ligature in the first lower molar sulcular area, and the animals were randomly assigned to different treatments (n = 10, each group) including daily peritoneal injections of saline solution (group A), submitted to self-administration of alcohol 25% (group B), nicotine solution in concentration 0.19 ?l/ml (group C), and nicotine solution in concentration 0.19 ?l/ml plus self-administration of alcohol 25% (group D). Five weeks later, the animal…
Intermittent administration of parathyroid hormone improves the repairing process of rat calvaria defects: A histomorphometric and radiodensitometric study
Background: The aim of this study was to evaluate the effects of intermittent treatment of parathyroid hormone (PTH (1-34)) on the bone regeneration of critically-sized rat calvarial bone defects. Material and Methods: Thirty-two male rats were trephined (4mm fullthickness diameter), in the central part of the parietal bones and divided into 2 groups of 16. The PTH group received subcutaneous injections of PTH (1-34) at 40μg/kg, 3 times a week and the control (CTL) group received the vehicle in the same regimen. The rats were sacrificed at 4 weeks post-treatment regimen, the parietal bones were extracted and samples were evaluated through histomorphometry and radiodensitometry. Results: The…