0000000000787864

AUTHOR

Orazio A. Attanasi

showing 2 related works from this author

A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin

2013

A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl compounds 12a-e and 1,2-diaza-1,3-diene (DD) 13. Derivatives 10a,c-e, deazaanalogues of the bis-indole alkaloid topsentin, screened by the National Cancer Institute (Bethesda, MD, USA) in the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity, with the exception of compound 9e, which showed moderate activity against the HOP-92 cell line of the non small cell lung cancer sub-p…

IndolesStereochemistryPharmaceutical ScienceAntineoplastic AgentsModerate activityArticleAnalytical Chemistrylcsh:QD241-441Alkaloidslcsh:Organic chemistrytopsentin; bis-indole alkaloids; antitumor activity; ethyl 1-[(<i>tert</i>-butoxycarbonyl)amino]-2-methyl-5-(1-methyl-1<i>H</i>-indol-3-yl)-4-[(1-methyl-1<i>H</i>-indol-3-yl)-carbonyl]-1<i>H</i>-pyrrole-3-carboxylatesCell Line Tumortopsentin; bis-indole alkaloids; antitumor activity; ethyl 1-[(tertbutoxycarbonyl) amino]-2-methyl-5-(1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)- carbonyl]-1H-pyrrole-3-carboxylatesDrug DiscoverymedicineHumansantitumor activityethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5-(1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)-carbonyl]-1H-pyrrole-3-carboxylatesPhysical and Theoretical ChemistryAntitumor activityethyl 1-[(tertbutoxycarbonyl) amino]-2-methyl-5-(1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)- carbonyl]-1H-pyrrole-3-carboxylatesChemistryAlkaloidOrganic ChemistryImidazolesCancermedicine.diseaseSettore CHIM/08 - Chimica FarmaceuticaIn vitroHuman tumorbis-indole alkaloidsChemistry (miscellaneous)Cell culturebis-indole alkaloidMolecular MedicineNon small cellDrug Screening Assays AntitumortopsentinMolecules; Volume 18; Issue 3; Pages: 2518-2527
researchProduct

Polycrystalline TiO2 impregnated with cardanol-based porphyrins for the photocatalytic degradation of 4-nitrophenol

2004

Hydrogenated cardanol (3-n-pentadecylphenol), a renewable organic resource obtained by vacuum distillation of roasted “cashew nut shell liquid” (CNSL), a by-product of the cashew industry, has been used to synthesize novel lipophilic porphyrins. Polycrystalline TiO2 impregnated with these novel “cardanol-based” porphyrins as sensitizers has been investigated in the photodegradation of 4-nitrophenol (4-NP) in aqueous suspension. The results indicated that the presence of the sensitizer enhances the photoactivity of polycrystalline bare TiO2 in the process. The activating effect was higher in the case of the Cu-complex.

Polycrystalline TiO2Vacuum distillationporphyrin derivativephotocatalytic degradationaldehydechemistry.chemical_compoundcrystallinEnvironmental ChemistryOrganic chemistrycardanolCashew nutPhotodegradationPhotocatalytic degradationcopper complexCardanoltitanium dioxide4 nitrophenol4-NitrophenolPollutionAqueous suspensionchemistryCrystalliteSettore CHIM/07 - Fondamenti Chimici Delle Tecnologieporphyrin4-nitrophenol.Nuclear chemistry
researchProduct