0000000000788884
AUTHOR
G Stassi
Cluster analysis of HVSR peak datasets to detect geological structures
A modified centroid-based algorithm has been applied to HVSR (Horizontal to Vertical Spectral Ratio) datasets (Nakamura, 2000) acquired for studies of seismic microzoning in various urban centers of Sicilian towns also aimed to obtain detailed reconstruction of the roof of the seismic bedrock (Di Stefano et al. 2014). HVSR data were previously properly processed to extract frequency and amplitude of peaks by a code based on clustering of HVSR curves determined in sliding time windows. In centroid-based clustering, clusters are represented by a central vector, which may not necessarily be a member of the data set. After fixing the number of clusters, the algorithm find the cluster centers an…
Mitochondrial disruption and apoptosis in lymphocytes of an HIV infected patient affected by lactic acidosis after treatment with highly active antiretroviral therapy
Aims: Highly active antiretroviral therapy (HAART) can induce an increase in lactic acid concentrations that seems to be caused by mitochondrial dysfunction induced by the interaction of nucleoside reverse transcriptase inhibitors (NRTIs) with DNA polymerase γ in the mitochondria. Mitochondrial alterations have been described in liver and muscle cells of NRTI treated human immunodeficiency virus (HIV) infected patients. Because lymphocytes are the main target for HIV and because mitochondria are involved in apoptosis, we studied mitochondrial morphology and apoptosis in the lymphocytes of an HIV infected patient with severe lactic acidosis after treatment with stavudine, didanosine, and ind…