0000000000789303
AUTHOR
Thomas Gustafsson
Observer-based control design for a class of nonlinear systems subject to unknown inputs: LMI approach
This paper deals with the problem of observer-based controller design for a class of nonlinear systems subject to unknown inputs. A novel method is presented to design a controller using estimated state variables which guarantees all the state variables of the closed-loop system converge to the vicinity of the origin and stay there forever. This is done via satisfying several sufficient conditions in terms of nonlinear matrix inequalities. In light of linear algebra, particularly matrix decompositions, the achieved conditions will be converted to a Linear Matrix Inequality (LMI) problem to facilitate the procedure of computing the observer and controller gains. Finally, the effectiveness of…
iGEMS : an integrated model for identification of alternative exon usage events
DNA microarrays and RNAseq are complementary methods for studying RNA molecules. Current computational methods to determine alternative exon usage (AEU) using such data require impractical visual inspection and still yield high false-positive rates. Integrated Gene and Exon Model of Splicing (iGEMS) adapts a gene-level residuals model with a gene size adjusted false discovery rate and exon-level analysis to circumvent these limitations. iGEMS was applied to two new DNA microarray datasets, including the high coverage Human Transcriptome Arrays 2.0 and performance was validated using RT-qPCR. First, AEU was studied in adipocytes treated with (n = 9) or without (n = 8) the anti-diabetes drug,…