showing 2 related works from this author
Steady-state generation of negative-Wigner-function light using feedback
2016
We propose a method of producing steady-state coherent light with negative Wigner functions in nonlinear media combined with feedback control. While the nonlinearities are essential to produce the Wigner negativities, this alone is insufficient to stabilize steady-state light with negativities. Using feedback control to control the phase in the cavity, we find that this produces significant total negativities for reasonable experimental parameters. The negative Wigner function is produced continuously and does not appear to be restricted to low-amplitude light. The technique is applicable to systems such as exciton-polaritons, where strong natural nonlinearities are present.
Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain
2018
The endocannabinoid system (ECS) is considered to be an endogenous protective system in various neurodegenerative diseases. Niemann-Pick type C (NPC) is a neurodegenerative disease in which the role of the ECS has not been studied yet. Most of the endocannabinoid enzymes are serine hydrolases, which can be studied using activity-based protein profiling (ABPP). Here, we report the serine hydrolase activity in brain proteomes of a NPC mouse model as measured by ABPP. Two ABPP methods are used: a gel-based method and a chemical proteomics method. The activities of the following endocannabinoid enzymes were quantified: diacylglycerol lipase (DAGL) α, α/β-hydrolase domain-containing protein 4, α…