Author: Melanie Döbel

0000000000795886

AUTHOR

Melanie Döbel

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Comparative analysis of fibrinolytic properties of Alteplase, Tenecteplase and Urokinase in an in vitro clot model of intracerebral haemorrhage.

2020

Abstract Objective Hematoma lysis with recombinant tissue plasminogen activator (rtPA) has emerged as an alternative therapy for spontaneous intracerebral and intraventricular haemorrhage (ICH and IVH). However, the MISTIE III and CLEAR III trial failed to show significant improvement of favourable outcomes. Besides experimental and clinical trials revealed neurotoxic effects of rtPA. The demand for optimization of fibrinolytic therapy persists. Herein, we used our recently devised clot model of ICH to systematically analyse fibrinolytic properties of rtPA, tenecteplase and urokinase. Methods In vitro clots of human blood (size: 25 ml and 50 ml; age: 1.5 tenecteplase, 24 tenecteplase and 48…

Time FactorsTenecteplase03 medical and health sciences0302 clinical medicineHematomaFibrinolytic AgentsmedicineHumansThrombolytic TherapyCerebral HemorrhageUrokinaseHuman bloodDose-Response Relationship Drugbusiness.industryOptimal treatmentFibrinolysisRehabilitationmedicine.diseaseUrokinase-Type Plasminogen ActivatorIn vitroCatheterAnesthesiaTissue Plasminogen ActivatorTenecteplaseSurgeryNeurology (clinical)Fibrinolytic therapyCardiology and Cardiovascular Medicinebusiness030217 neurology & neurosurgerymedicine.drugJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

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