0000000000800745

AUTHOR

Harald Osmundsen

showing 2 related works from this author

Metabolic effects of omega-3 fatty acids.

2001

Some metabolic effects of dietary marine oils, or of dietary eicosapentaenoic or docosahexaenoic acid are reviewed. It is pointed out that docosahexaenoic acid appears more effective as regards induction of peroxisomal beta-oxidation. Similarly, docosahexaenoic appears more powerful in terms of suppression of hepatic delta9-desaturase activity and mRNA-levels. The potential inhibitory effect of polyunsaturated fatty acids, particularly docosahexaenoic acid, on mitochondrial beta-oxidation is discussed. Experiments with rats suggesting that the hypolipidaemic response of eicosapentaenoic acid is more marked when the fatty acid was given to fed rats, as compared to fasted rats, are discussed.

chemistry.chemical_classificationClinical BiochemistryFatty acidGeneral MedicineMetabolismBiologyPeroxisomeMitochondrionBiochemistryEicosapentaenoic acidMitochondriaFish OilsBiochemistrychemistryDietary Fats UnsaturatedLiverDocosahexaenoic acidFatty Acids Omega-3PeroxisomesMolecular MedicineAnimalsHumansCYP2C8Stearoyl-CoA DesaturasePolyunsaturated fatty acidBioFactors (Oxford, England)
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Effects of dietary treatment of rats with eicosapentaenoic acid or docosahexaenoic acid on hepatic lipid metabolism

1998

(1) Effects of dietary treatment of male albino rats with eicosapentaenoic acid (EPA) or docosahexaenoic acid on hepatic mitochondrial lipid metabolism have been investigated. (2) Mitochondria isolated from rats given these treatments were shown to have increased ability to respire on acyl-CoA esters in the presence of malonate. This effect was expressed with most of the long-chain acyl-CoA esters used as substrates. When malonate in the incubations was replaced with malate, mitochondria from treated animals were found to exhibit diminished rates of respiration on polyunsaturated acyl-CoA esters, in particular linolenoyl-, eicosapentaenoyl- and docosahexaenoyl-CoA. This phenomenon could not…

Malemedicine.medical_specialtyDocosahexaenoic AcidsMitochondria LiverBiochemistryLipid peroxidationchemistry.chemical_compoundFish OilsInternal medicinemedicineAnimalsRats WistarMolecular Biologychemistry.chemical_classificationFatty acidLipid metabolismCell BiologyMetabolismLipid MetabolismEicosapentaenoic acidDietRatsEndocrinologyEicosapentaenoic AcidLiverchemistryBiochemistryDocosahexaenoic acidCarnitine biosynthesislipids (amino acids peptides and proteins)Lipid PeroxidationCarnitine palmitoyltransferase IResearch ArticleBiochemical Journal
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