0000000000802479

AUTHOR

István Zupkó

showing 11 related works from this author

Stereoselective Synthesis and Cytoselective Toxicity of Monoterpene-Fused 2-Imino-1,3-thiazines

2014

Starting from pinane-, apopinane- and carane-based 1,3-amino alcohols obtained from monoterpene-based β-amino acids, a library of monoterpene-fused 2-imino-1,3-thiazines as main products and 2-thioxo-1,3-oxazines as side-products were prepared via two- or three-step syntheses. When thiourea adducts prepared from 1,3-amino alcohols and aryl isothiocyanates were reacted with CDI under mild conditions, O-imidazolylcarbonyl intermediates were isolated which could be transformed to the desired 1,3-thiazines under microwave conditions. 1,3-Thiazines and 2-thioxo-1,3-oxazine side-products could also be prepared in one-step reactions through the application of CDI and microwave irradiation. The rin…

MonoterpeneMolecular ConformationThiazinesPharmaceutical ScienceStereoisomerismArticleAnalytical ChemistryAdductHeLalcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistryantiproliferativeCell Line TumorDrug DiscoveryOrganic chemistryHumansPhysical and Theoretical Chemistryta116Cell ProliferationbiologystereoselectiveArylOrganic Chemistry13-thiazineStereoisomerismbiology.organism_classificationCycloalkanechemistryThiourea13-amino alcoholChemistry (miscellaneous)MonoterpenesMolecular MedicineStereoselectivityCDImonoterpeneMolecules
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Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes

2013

Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1–S transiton as evidenced by flow cytometry.

Cisplatinmedicine.diagnostic_testStereochemistryOrganic Chemistrychemistry.chemical_elementCell cycleFlow cytometryRutheniumInorganic ChemistryConcentration dependentchemistryCyclopentadienyl complexCancer cellmedicineCytotoxic T cellPhysical and Theoretical Chemistryta116medicine.drugOrganometallics
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Synthesis and biological evaluation of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine and its cycloalkane and cycloa…

2021

Derivatives of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepinone and its cycloalkane and cycloalkene condensed analogues have been conveniently synthesized through a three-step reaction sequence. An atom-economical, one-pot, three-step cascade process engaging five reactive centers (amide, amine, carbonyl, azide, and alkyne) has been performed for the synthesis of alicyclic derivatives of quinazolinotriazolobenzodiazepine using cyclohexane, cyclohexene, and norbornene β-amino amides. The stereochemistry and relative configurations of the synthesized compounds were determined by 1D and 2D NMR spectroscopy and X-ray crystallography. The reaction was also perfor…

kemiallinen synteesibioaktiiviset yhdisteettyppiyhdisteetorgaaniset yhdisteet
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Synthesis and biological evaluation of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine and its cycloalkane and cycloa…

2021

Derivatives of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepinone and its cycloalkane and cycloalkene condensed analogues have been conveniently synthesized through a three-step reaction sequence. An atom-economical, one-pot, three-step cascade process engaging five reactive centers (amide, amine, carbonyl, azide, and alkyne) has been performed for the synthesis of alicyclic derivatives of quinazolinotriazolobenzodiazepine using cyclohexane, cyclohexene, and norbornene β-amino amides. The stereochemistry and relative configurations of the synthesized compounds were determined by 1D and 2D NMR spectroscopy and X-ray crystallography. The reaction was also perfor…

chemistry.chemical_classificationGeneral Chemical EngineeringCyclohexeneAlkyneGeneral ChemistryMedicinal chemistrychemistry.chemical_compoundCycloalkaneDiazepinechemistryAmideAzideCycloalkeneNorborneneRSC Advances
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CCDC 2048904: Experimental Crystal Structure Determination

2021

Related Article: Mohamed El Haimer, Márta Palkó, Matti Haukka, Márió Gajdács, István Zupkó, Ferenc Fülöp|2021|RSC Advances|11|6952|doi:10.1039/D0RA10553H

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters11a1213141515a1616a-octahydro-9H11H-quinazolino[32-d][123]triazolo[15-a][14]benzodiazepin-11-oneExperimental 3D Coordinates
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CCDC 1000178: Experimental Crystal Structure Determination

2015

Related Article: Zsolt Szakonyi, István Zupkó, Reijo Sillanpää and Ferenc Fülöp|2014|Molecules|19|15918|doi:10.3390/molecules191015918

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates(2-(((3-methoxyphenyl)carbamothioyl)amino)-66-dimethylbicyclo[3.1.1]hept-3-yl)methyl 1H-imidazole-1-carboxylate
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CCDC 929860: Experimental Crystal Structure Determination

2013

Related Article: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, and Reko Leino|2013|Organometallics|32|3012|doi:10.1021/om400234p

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(eta^5^-47-Dimethyl-123-tris(4-methylbenzyl)-1H-indenyl)-docarbonyl-chloro-rutheniumExperimental 3D Coordinates
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CCDC 929859: Experimental Crystal Structure Determination

2013

Related Article: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, and Reko Leino|2013|Organometallics|32|3012|doi:10.1021/om400234p

Space GroupCrystallography(eta^5^-2-Benzoyloxy-13-diphenyl-1H-cyclopenta[l]phenanthrenyl)-dicarbonyl-chloro-rutheniumCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2048905: Experimental Crystal Structure Determination

2021

Related Article: Mohamed El Haimer, Márta Palkó, Matti Haukka, Márió Gajdács, István Zupkó, Ferenc Fülöp|2021|RSC Advances|11|6952|doi:10.1039/D0RA10553H

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters11a1213141515a1616a-octahydro-9H11H-quinazolino[32-d][123]triazolo[15-a][14]benzodiazepin-11-oneExperimental 3D Coordinates
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CCDC 2048906: Experimental Crystal Structure Determination

2021

Related Article: Mohamed El Haimer, Márta Palkó, Matti Haukka, Márió Gajdács, István Zupkó, Ferenc Fülöp|2021|RSC Advances|11|6952|doi:10.1039/D0RA10553H

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates2-bromo-11a121515a1616a-hexahydro-9H11H-1215-methanoquinazolino[32-d][123]triazolo[15-a][14]benzodiazepin-11-one
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CCDC 1000179: Experimental Crystal Structure Determination

2015

Related Article: Zsolt Szakonyi, István Zupkó, Reijo Sillanpää and Ferenc Fülöp|2014|Molecules|19|15918|doi:10.3390/molecules191015918

(2-(((4-fluorophenyl)carbamothioyl)amino)-66-dimethylbicyclo[3.1.1]hept-3-yl)methyl 1H-imidazole-1-carboxylateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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