6533b83afe1ef96bd12a6f6e
RESEARCH PRODUCT
Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes
Denys MavrynskyMikko M. HänninenDaniel BandarraIstván ZupkóReko LeinoJani RahkilaMaria José CalhordaSoraia MartinsMargarida MeirelesIda Kovácssubject
Cisplatinmedicine.diagnostic_testStereochemistryOrganic Chemistrychemistry.chemical_elementCell cycleFlow cytometryRutheniumInorganic ChemistryConcentration dependentchemistryCyclopentadienyl complexCancer cellmedicineCytotoxic T cellPhysical and Theoretical Chemistryta116medicine.drugdescription
Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1–S transiton as evidenced by flow cytometry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-05-09 | Organometallics |