Porous materials as delivery and protective agents for Vitamin A
The suitability of porous materials to immobilize and release under control bioactive molecules prompted us to design and study delivery systems of Vitamin A (VitA). This molecule, relevant in several physiological functions, is easily oxidized. Commercial VitA was immobilized in two different clays, montmorillonite K-10 (MMT) and sepiolite (SEP), and in MCM-41, by impregnation. Characterization of the resulting hybrid materials by XRD, FTIR and 13C and 29Si (MAS) NMR spectroscopies revealed its presence. The photo-stability tests showed decreased degradation of VitA in the clays, compared to MCM-41 and the pure VitA, while thermostability is observed until ∼100 °C. The kinetics of the rele…
Solvent-dependent formation of Os(0) complexes by electrochemical reduction of [Os(CO)(2,2'-bipyridine)(L)Cl2]; L = Cl(-), PrCN.
Cyclic voltammetry and ultraviolet-visible/infrared (UV-vis/IR) spectroelectrochemistry were used to study the cathodic electrochemical behavior of the osmium complexes mer-[Os(III)(CO) (bpy)Cl3] (bpy = 2,2'-bipyridine) and trans(Cl)-[Os(II)(CO) (PrCN)(bpy)Cl2] at variable temperature in different solvents (tetrahydrofuran (THF), butyronitrile (PrCN), acetonitrile (MeCN)) and electrolytes (Bu4NPF6, Bu4NCl). The precursors can be reduced to mer-[Os(II)(CO) (bpy(•-))Cl3](2-) and trans(Cl)-[Os(II)(CO)(PrCN) (bpy(•-))Cl2](-), respectively, which react rapidly at room temperature, losing the chloride ligands and forming Os(0) species. mer-[Os(III)(CO) (bpy)Cl3] is reduced in THF to give ultimate…
Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes
Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1–S transiton as evidenced by flow cytometry.
CCDC 986566: Experimental Crystal Structure Determination
Related Article: Joanne Tory , Lisa King, Antonios Maroulis , Matti Haukka , Maria José Calhorda , and František Hartl|2014|Inorg.Chem.|53|1382|doi:10.1021/ic402146t
CCDC 929860: Experimental Crystal Structure Determination
Related Article: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, and Reko Leino|2013|Organometallics|32|3012|doi:10.1021/om400234p
CCDC 986567: Experimental Crystal Structure Determination
Related Article: Joanne Tory , Lisa King, Antonios Maroulis , Matti Haukka , Maria José Calhorda , and František Hartl|2014|Inorg.Chem.|53|1382|doi:10.1021/ic402146t
CCDC 929859: Experimental Crystal Structure Determination
Related Article: Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, and Reko Leino|2013|Organometallics|32|3012|doi:10.1021/om400234p