0000000000802558

AUTHOR

Mari Carmen Badia

showing 1 related works from this author

Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage.

2015

Abstract Alzheimer disease (AD) is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition. Amyloid-s-peptide (As) forms senile plaques, which, together with hyperphosphorylated tau-based neurofibrillary tangles, are the hallmarks of AD neuropathology. Evidence support the involvement of immune system in AD progression and current concepts regarding its pathogenesis include the participation of inflammatory and autoimmune components in the neurodegenerative process. Pathologically, immune system components have been detected in the brain, cerebrospinal fluid (CSF) and in serum of AD subjects and their trend of variation correlates …

0301 basic medicineMalePathologymedicine.medical_specialtyBlotting WesternNeuropathologyaged; aged 80 and over; alzheimer disease; autoantibodies; biomarkers; blotting western; cognitive dysfunction; female; frontal lobe; humans; male; mass spectrometry; oxidative stressmedicine.disease_causeMass SpectrometryAutoimmunity03 medical and health sciences0302 clinical medicineCerebrospinal fluidImmune systemAlzheimer DiseasemedicineDementiaHumansCognitive DysfunctionSenile plaquesAgedAutoantibodiesAged 80 and overAutoantibodymedicine.diseaseFrontal LobeOxidative Stress030104 developmental biologyNeurologyImmunologyFemaleNeurology (clinical)Alzheimer's diseasePsychology030217 neurology & neurosurgeryBiomarkersCurrent Alzheimer research
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