0000000000803242

AUTHOR

Nadine Gehrke

showing 3 related works from this author

Supp_1 – Supplemental material for Cytokeratin-18 fragments predict treatment response and overall survival in gastric cancer in a randomized control…

2018

Supplemental material, Supp_1 for Cytokeratin-18 fragments predict treatment response and overall survival in gastric cancer in a randomized controlled trial by Michael Nagel, Julia Schulz, Annett Maderer, Katrin Goepfert, Nadine Gehrke, Thomas Thomaidis, Peter C Thuss-Patience, Salah E Al-Batran, Susanna Hegewisch-Becker, Peter Grimminger, Peter Robert Galle, Markus Möhler and Jörn Markus Schattenberg in Tumor Biology

FOS: Clinical medicineCell Biology111299 Oncology and Carcinogenesis not elsewhere classified
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Formalin-Fixed <i>Staphylococcus aureus</i> Particles Prevent Allergic Sensitization in a Murine Model of Type I Allergy

2007

<i>Background:</i> Bacterial infections are supposed to act counterregulatory to the development of allergen-specific Th2 immune responses. We analyzed whether administration of extracellular <i>Staphylococcus aureus</i> inhibited experimental sensitization against allergens. <i>Methods:</i> BALB/c mice were immunized with alum-adsorbed ovalbumin (OVA) together with formalin-fixed <i>Staphylococcus</i> particles. OVA-specific antibody production and cytokine synthesis by spleen cells was analyzed. Airway reactivity and cellular infiltration into the airways was assessed after intranasal challenge of mice with OVA. In addition, the capacity of …

Allergybiologybusiness.industryImmunologyGeneral Medicinemedicine.diseaseImmunoglobulin Emedicine.disease_causeAllergic sensitizationImmune systemmedicine.anatomical_structureHygiene hypothesisStaphylococcus aureusImmunopathologyImmunologymedicinebiology.proteinImmunology and AllergybusinessSensitizationInternational Archives of Allergy and Immunology
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Divergent effects of biolistic gene transfer in a mouse model of allergic airway inflammation.

2007

Particle-mediated epidermal delivery (PMED) of allergen genes efficiently prevents systemic sensitization and suppresses specific immunoglobulin E synthesis. We investigated in a mouse model of allergic airway disease the effect of PMED on the elicitation of local inflammatory reactions in the lung. BALB/c mice were biolistically transfected with plasmids encoding beta-galactosidase (betaGal) as model allergen under control of the DC-targeting fascin promoter and the ubiquitously active cytomegalovirus promoter, respectively. Mice were challenged intranasally with betaGal-protein with or without intermediate sensitization with betaGal adsorbed to aluminiumhydroxide. Subsequently, local cyto…

Pulmonary and Respiratory Medicinemedicine.medical_treatmentClinical BiochemistryCytomegalovirusBiologymedicine.disease_causeDNA vaccinationInterferon-gammaMiceAllergenTh2 CellsmedicineRespiratory HypersensitivityAnimalsHumansPromoter Regions GeneticMolecular BiologyLungSensitizationCells CulturedInflammationMice Inbred BALB Cmedicine.diagnostic_testMicrofilament ProteinsGene Transfer TechniquesCell BiologyTransfectionDendritic Cellsrespiratory systemImmunoglobulin ETh1 Cellsmedicine.diseasebeta-Galactosidaserespiratory tract diseasesCellular infiltrationDisease Models Animalmedicine.anatomical_structureBronchoalveolar lavageCytokineNeutrophil InfiltrationImmunologyAntibody FormationFemaleEpidermisCarrier ProteinsBronchoalveolar Lavage FluidCD8T-Lymphocytes CytotoxicAmerican journal of respiratory cell and molecular biology
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