0000000000804724
AUTHOR
Philippe Fernandez
Le gisement pléistocène moyen récent de Romain-la-Roche (Doubs, France) :synthèse biostratigraphique et paléoécologique
International audience; The Uppermost Middle Pleistocene site of Romain-la-Roche (Doubs, France) : synthesis of biostratigraphic and palaeoecological conclusions.- The site of Romain-la-Roche is a karstic swallowhole which acted as a natural trap where fall numerous large mammals, and where diverse small vertebrates were transported as preys of birds. The site was excavated between 1980 and 1991 by Patrick Paupe and his team. It yielded 52 species of mammals (more than 10 000 identifiable remains), more than 13 of species of birds, two of reptiles, one of amphibian, two of fishes and undetermined gastropods. Among the mammalian species 34.6 % are of rodents (3975 remains), 9.6 % insectivore…
Designing Silylatedl-Amino Acids using a Wittig Strategy: Synthesis of Peptide Derivatives and18F-Labelling
An efficient semisynthesis of silylated l-amino acids by reaction of silylated benzaldehydes with a phosphonium l-amino acid used as a Wittig reagent is described. The efficiency of the silylated l-amino acids in peptide synthesis was investigated by coupling both the carboxylic acid and the amino moiety with l-alanine and phenylalanine derivatives, respectively. The silylated derivatives were treated with KF or tetrabutylammonium fluoride to give the corresponding fluorosilyl derivatives without racemization. The hydrolysis of the fluorosilylated derivatives in phosphate buffer at pH 7.2 was checked. Finally, the 18F-labelling of di-tert-butylsilylated saturated and unsaturated dipeptides …