0000000000809063

AUTHOR

Harousseau Jl

showing 2 related works from this author

Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells.

1999

Abstract Circulating plasma cells in 10 cases of reactive plasmacytosis had a shared phenotype with early plasma cell (CD19+CD38+ CD138+ CD40+CD45+ CD11a+ CD49e−CD56−). In most cases, a minor subpopulation of CD28+ plasma cells was also detected. Reactive plasma cells were highly proliferative, suggesting the presence of circulating progenitors (plasmablasts). After CD138+ plasma cell removal, highly proliferative CD138− plasmablasts differentiated into CD138+ plasma cells within a few days. This differentiation, which was associated with increased CD38 and decreased HLA-DR expression, was further confirmed by a large increase in intracellular Ig content (associated with Ig secretion) and w…

MaleCellular differentiationRemission SpontaneousApoptosisCD38Plasma cellBiochemistry0302 clinical medicineimmune system diseaseshemic and lymphatic diseasesChildCells Cultured[INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]0303 health sciencesbiologyAntibodies MonoclonalCell DifferentiationHematologyMiddle Agedmedicine.anatomical_structureFemaleAntibodyMultiple MyelomaAdultPlasma CellsImmunologyLymphocytosisCD19ImmunophenotypingImmunoglobulin kappa-Chains03 medical and health sciencesImmunoglobulin lambda-ChainsAntigens CD[ INFO.INFO-BI ] Computer Science [cs]/Bioinformatics [q-bio.QM]medicineHumansProgenitor cellAgedRetrospective Studies030304 developmental biologyCD40Interleukin-6PlasmacytosisCell Biologymedicine.diseaseHematopoietic Stem CellsMolecular biologyReceptors Interleukin-6Immunologybiology.protein[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]030215 immunology
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CD28, a marker associated with tumoral expansion in multiple myeloma

1998

International audience; CD28 expression was thoroughly investigated on plasma cells of monoclonal gammopathy of undetermined significance, multiple myeloma (MM), and human myeloma cell lines. CD28+ plasma cells were detected in 19% of 31 monoclonal gammopathy of undetermined significance, 41% of 116 MM, and 100% of 13 human myeloma cell lines. CD28+ myeloma cells were detected in 21 of 79 (26%) MM cases at diagnosis, 13 of 22 (59%) at medullary relapse (P < 0.009), and 14 of 15 (93%) at extramedullary relapse (P = 0.05), including 10 of 10 (100%) secondary plasma cell leukemias (P = 0.05). Serial studies in individual patients confirmed the emergence of CD28+ myeloma cells with tumoral expa…

Membrane GlycoproteinsParaproteinemiasNeoplasms Second Primarychemical and pharmacologic phenomenahemic and immune systemsCD56 AntigenCell LineLeukemia Plasma CellCD28 AntigensAntigens CDBone MarrowPredictive Value of TestsRecurrence[ INFO.INFO-BI ] Computer Science [cs]/Bioinformatics [q-bio.QM]hemic and lymphatic diseasesB7-1 AntigenBiomarkers TumorDisease ProgressionTumor Cells CulturedHumansB7-2 AntigenTreatment Failure[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]Multiple Myeloma[INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]
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