Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells.

6533b828fe1ef96bd1287aea

RESEARCH PRODUCT

Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells.

Harousseau Jl Régis Bataille Françoise Accard Catherine Pellat-deceunynck Martine Amiot Denis Puthier Danielle Pineau Nelly Robillard Gaëtan Jego

subject

Male Cellular differentiation Remission Spontaneous Apoptosis CD38 Plasma cell Biochemistry 0302 clinical medicine immune system diseases hemic and lymphatic diseases Child Cells Cultured [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]0303 health sciences biology Antibodies Monoclonal Cell Differentiation Hematology Middle Aged medicine.anatomical_structure Female Antibody Multiple Myeloma Adult Plasma Cells Immunology Lymphocytosis CD19 Immunophenotyping Immunoglobulin kappa-Chains 03 medical and health sciences Immunoglobulin lambda-Chains Antigens CD [ INFO.INFO-BI ] Computer Science [cs]/Bioinformatics [q-bio.QM]medicine Humans Progenitor cell Aged Retrospective Studies 030304 developmental biology CD40 Interleukin-6 Plasmacytosis Cell Biology medicine.disease Hematopoietic Stem Cells Molecular biology Receptors Interleukin-6 Immunology biology.protein [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]030215 immunology

description

Abstract Circulating plasma cells in 10 cases of reactive plasmacytosis had a shared phenotype with early plasma cell (CD19+CD38+ CD138+ CD40+CD45+ CD11a+ CD49e−CD56−). In most cases, a minor subpopulation of CD28+ plasma cells was also detected. Reactive plasma cells were highly proliferative, suggesting the presence of circulating progenitors (plasmablasts). After CD138+ plasma cell removal, highly proliferative CD138− plasmablasts differentiated into CD138+ plasma cells within a few days. This differentiation, which was associated with increased CD38 and decreased HLA-DR expression, was further confirmed by a large increase in intracellular Ig content (associated with Ig secretion) and was concomitant with extensive secretion of interleukin-6 (IL-6). The addition of neutralizing anti–IL-6 and anti-CD126 (IL-6 receptor) monoclonal antibodies totally prevented Ig secretion and cell differentiation by inducing apoptosis of plasmablasts, which indicates that IL-6 is an essential survival factor for plasmablasts. This report provides the first characterization of normal plasmablasts and shows that their phenotype is not exactly that of multiple myeloma cells.

year	journal	country	edition	language
1999-07-01

http://europepmc.org/abstract/med/10397737