In utero fetal liver hematopoietic stem cell transplantation: is there a role for alloreactive T lymphocytes?

The use of hematopoietic stem cells for in utero transplantation to create permanent hematochimerism represents a new concept in fetal therapy, although this approach has provided quite heterogeneous results. Flake and Zanjani have provided an excellent updated review of the current knowledge of in