0000000000810807

AUTHOR

Dieudonné Emmanuel Pegnyemb

showing 3 related works from this author

Cytotoxic Acacic Acid Glycosides from the Roots of Albizia coriaria

2009

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.

SaponinPharmaceutical ScienceAlbizziaPharmacognosyPlant RootsAnalytical ChemistryTriterpeneCoriariaDrug DiscoveryBotanyHumansCameroonOleanolic AcidMedicinal plantsNuclear Magnetic Resonance BiomolecularPharmacologychemistry.chemical_classificationPlants MedicinalMolecular StructurebiologyOrganic ChemistryGlycosideSaponinsHCT116 Cellsbiology.organism_classificationAlbiziaAntineoplastic Agents PhytogenicTriterpenesTerpenoidComplementary and alternative medicinechemistryMolecular MedicineDrug Screening Assays AntitumorHT29 CellsJournal of Natural Products
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Tetrapterosides A and B, two new oleanane-type saponins fromTetrapleura tetraptera

2009

From the stem bark of Tetrapleura tetraptera, two new oleanane-type saponins, tetrapteroside A 3-O-{6-O-[(2E,6S)-2,6-dimethyl-6-hydroxyocta-2,7-dienoyl]-beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl}-3,27-dihydroxyoleanolic acid (1), and tetrapteroside B 3-O-{ beta-D-glucopyranosyl-(1 --> 2)-6-O-[(E)-feruloyl]-beta-D-glucopyranosyl-(1 --> 3)-beta-D-glucopyranosyl-(1 --> 4)-[beta-D-glucopyranosyl-(1 --> 2)]-beta-D-glucopyranosyl}-3,27-dihydroxyoleanolic acid (2), were isolated. Further extractions from the roots led to the isolation of four known oleanane-type saponins. Their structures …

Stem barkMagnetic Resonance SpectroscopyMolecular StructureTetrapleura tetrapterabiologyStereochemistryChemistryTetrapteroside BGeneral ChemistryNuclear magnetic resonance spectroscopySaponinsType (model theory)biology.organism_classificationchemistry.chemical_compoundTetrapleuraGeneral Materials ScienceTetrapleuraTwo-dimensional nuclear magnetic resonance spectroscopyOleananeMagnetic Resonance in Chemistry
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Triterpenoid saponins from Piptadeniastrum africanum (Hook. f.) Brenan

2013

One new triterpenoid saponin, named piptadeniaoside (1), along with two known saponins (2–3) have been isolated from the stem bark of Piptadeniastrum africanum. After previous isolation of flavone derivatives from this plant, new phytochemical investigations were performed for its saponin content. Their structures were established by direct interpretation of their spectral data, mainly HRESIMS, 1D NMR (1H, 13C NMR, DEPT) and 2D NMR (COSY, NOESY, HSQC and HMBC), and by comparison with the literature data.

chemistry.chemical_classificationTraditional medicineChemistryStereochemistrySaponinPlant ScienceDEPTCarbon-13 NMRBiochemistrychemistry.chemical_compoundPhytochemicalAgronomy and Crop ScienceTwo-dimensional nuclear magnetic resonance spectroscopyOleanolic acidHeteronuclear single quantum coherence spectroscopyBiotechnologyTriterpenoid saponinPhytochemistry Letters
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