6533b834fe1ef96bd129e0cd

RESEARCH PRODUCT

Cytotoxic Acacic Acid Glycosides from the Roots of Albizia coriaria

Olivier Placide NotéAnne Claire Mitaine-offerTomofumi MiyamotoThomas PaululatJean-françois MirjoletOlivier DuchampDieudonné Emmanuel PegnyembMarie Aleth Lacaille-dubois

subject

SaponinPharmaceutical ScienceAlbizziaPharmacognosyPlant RootsAnalytical ChemistryTriterpeneCoriariaDrug DiscoveryBotanyHumansCameroonOleanolic AcidMedicinal plantsNuclear Magnetic Resonance BiomolecularPharmacologychemistry.chemical_classificationPlants MedicinalMolecular StructurebiologyOrganic ChemistryGlycosideSaponinsHCT116 Cellsbiology.organism_classificationAlbiziaAntineoplastic Agents PhytogenicTriterpenesTerpenoidComplementary and alternative medicinechemistryMolecular MedicineDrug Screening Assays AntitumorHT29 Cells

description

Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.

yearjournalcountryeditionlanguage
2009-09-24Journal of Natural Products
https://doi.org/10.1021/np900126r