0000000000812669
AUTHOR
Danila Barskiy
Zero-Field J-spectroscopy of Quadrupolar Nuclei
Zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is a version of NMR that allows studying molecules and their transformations in the regime dominated by intrinsic spin-spin interactions. While spin dynamics at zero magnetic field can be probed indirectly, J-spectra can also be measured at zero field by using non-inductive sensors, for example, optically-pumped magnetometers (OPMs). A J-spectrum can be detected when a molecule contains at least two different types of magnetic nuclei (i.e., nuclei with different gyromagnetic ratios) that are coupled via J-coupling. Up to date, no pure J-spectra of molecules featuring the coupling to quadrupolar nuclei were reported. Here we sho…
13C and 15N NMR Detection of Metabolites via Relayed Hyperpolarization at 1 T and 1.4 T
Nuclear-spin hyperpolarization allows various magnetic-resonance applications in chemistry and medicine that are unattainable by standard methods. For such applications, parahydrogen-based hyperpolarization approaches are particularly attractive because of their technical simplicity, low cost, and ability to quickly (in seconds) produce large volumes of hyperpolarized material. Although many parahydrogen-based techniques have emerged, some of them remain unexplored due to the lack of careful optimization studies. In this work, we investigate and optimize a novel parahydrogen-induced polarization (PHIP) technique that relies on proton exchange referred to below as PHIP-relay. An INEPT (insen…