Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage
International audience; Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb-restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the ent…
Potential treatment strategy for the rare osimertinib resistant mutation EGFR L718Q
Epidermal growth factor receptor (EGFR) L718Q is a rare resistant mutation which independently leads to third-generation tyrosine kinase inhibitor (TKI) resistance. Although a few studies have examined its resistance mechanisms, no effective treatment strategy has yet been proposed for patients with this mutation. Here, we report an effective treatment strategy for the rare EGFR L718Q mutation for the first time. A 44-year-old Chinese male patient initially presented with the sensitizing EGFR L858R mutation, and the progression-free survival (PFS) time after initial icotinib treatment was 9 months. When the progression of the disease (PD) and the EGFR T790M mutation were identified, he did …
Evaluating soil erosion and sediment deposition rates by the 137Cs fingerprinting technique at karst gabin basin in Yunnan Province, southwest China
Soil erosion is a global environmental problem that can lead to the loss of nutrients in topsoil layers, particularly in fragile karst environments where the low contents of organic carbon and steep slopes used to be key pedological and geomorphological factors. Researching the erosion and deposition rates in small watersheds is important for designing efficient soil and water conservation measures. In this research, the Dapotou closed catchment, a representative depression in karst gabin basin, located in the Yunnan province, Southwest China, was selected to assess the variation of soil erosion and soil sediment mobilisation at different hillslope positions using the 137Cs tracing techniqu…