6533b835fe1ef96bd129ebc3
RESEARCH PRODUCT
Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage
Fathia Mami-chouaibVincent CattoirGuido KroemerMohamed SassiKrisztián PappNathalie LabarrièreValerio IebbaValerio IebbaValerio IebbaValentin QuiniouRomain BoidotZsofia SztupinszkiNicola SegataIvo G. BonecaFriedemann LoosSylvain SimonJacques Bou-khalilRichard J. WheelerCarlos López-otínAndréanne GagnéLuisa De SordiLuisa De SordiBarbara S. SixtPhilippe JoubertClara-maria ScarlataFabien LemaitrePeng LiuLaurent DebarbieuxAlexander M.m. EggermontPaola NisticòDidier RaoultDavid KlatzmannConnie P.m. DuongConnie P.m. DuongBelinda PalermoLisa DerosaLisa DerosaLisa DerosaMaha AyyoubMaryam Tidjani AlouMaryam Tidjani AlouMaryam Tidjani AlouMeriem MessaoudeneB. EscudierB. EscudierFrançois GhiringhelliAurélie FluckigerAurélie FluckigerGladys FerrereGladys FerrereSaber KhelaifiaBertrand RoutyLaurence AlbigesEdoardo PasolliAnne Gaëlle GoubetAnne Gaëlle GoubetZoltan SzallasiRomain DaillèreRomain DaillèreIstván CsabaiLaurence ZitvogelFabrice AndreFrancesco FaccioloCorentin RichardCatherine Rabusubject
H-2 AntigenProgrammed Cell Death 1 ReceptorCD8-Positive T-LymphocytesEpitopeEpitopesFecesMice0302 clinical medicineEnterococcus hiraeNeoplasmsMonoclonalBacteriophages0303 health sciencesMultidisciplinarybiologyAntibodies MonoclonalViral Tail ProteinsAlkylating3. Good healthmedicine.anatomical_structure030220 oncology & carcinogenesisCross ReactionEpitopeImmunotherapyHumanT cellAntineoplastic Agents[SDV.CAN]Life Sciences [q-bio]/CancerCross ReactionsMajor histocompatibility complexAntibodiesMicrobiology03 medical and health sciencesAnimals; Antibodies Monoclonal; Antigens Neoplasm; Antineoplastic Agents Alkylating; Bacteriophages; CD8-Positive T-Lymphocytes; Cross Reactions; Cyclophosphamide; Enterococcus hirae; Epitopes; Feces; Gastrointestinal Microbiome; H-2 Antigens; Histocompatibility Antigens Class I; Humans; Immunotherapy; Mice; Neoplasms; Programmed Cell Death 1 Receptor; Viral Tail Proteins[SDV.CAN] Life Sciences [q-bio]/CancerAntigenAntigens NeoplasmMHC class ImedicineAnimalsHumansAntigensBacteriophageAntineoplastic Agents AlkylatingCyclophosphamideProphage030304 developmental biologyEnterococcus hiraeAnimalHistocompatibility Antigens Class IH-2 AntigensCD8-Positive T-Lymphocytebiology.organism_classificationGastrointestinal Microbiomebiology.proteinNeoplasmFeceCD8description
International audience; Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb-restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-08-21 |