0000000000815555
AUTHOR
P. Marotta
Cost effectiveness of peginterferon α-2b plus ribavirin versus interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C
Background: Peginterferon α-2b plus ribavirin therapy in previously untreated patients with chronic hepatitis C yields the highest sustained virological response rates of any treatment strategy but is expensive. Aims: To estimate the cost effectiveness of treatment with peginterferon α-2b plus ribavirin compared with interferon α-2b plus ribavirin for initial treatment of patients with chronic hepatitis C. Methods: Individual patient level data from a randomised clinical trial with peginterferon plus ribavirin were applied to a previously published and validated Markov model to project lifelong clinical outcomes. Quality of life and economic estimates were based on German patient data. We u…
Effects of Ribavirin Dose Reduction vs Erythropoietin for Boceprevir-Related Anemia in Patients With Chronic Hepatitis C Virus Genotype 1 Infection—A Randomized Trial
International audience; Background & AimsTreatment of hepatitis C virus (HCV) infection with boceprevir, peginterferon, and ribavirin can lead to anemia, which has been managed by reducing ribavirin dose and/or erythropoietin therapy. We assessed the effects of these anemia management strategies on rates of sustained virologic response (SVR) and safety.MethodsPatients (n = 687) received 4 weeks of peginterferon and ribavirin followed by 24 or 44 weeks of boceprevir (800 mg, 3 times each day) plus peginterferon and ribavirin. Patients who became anemic (levels of hemoglobin approximately ≤10 g/dL) during the study treatment period (n = 500) were assigned to groups that were managed by ribavi…
Trasformazioni delle città contemporanee tra pubblico e privato. Centri commerciali tra gli agrumeti storici di Palermo
In the last fifty years the governance and the transformations of cities reflects the phase of “uncertainty” produced by the formation of a new frame of spatial planning practises. At the moment, the way of planning the urban and territorial transformations, and the different possibilities to realise a project, are regulated by new forms of relationships between public and private. If from one side, new forms of negotiated actions between public and private actors make possible a larger flexibility in the process of transformation, from the other side, the general vision defined by the plan is lost and the risk is to generate an irreversible process of transformation. This situation occurs …
Il territorio e l'uso delle energie rinnovabili nella città
In Italia, secondo quanto riportato nell’Annuario dei Dati Ambientali del 2010, redatto a cura dell’Ispra, le emissioni di gas serra sono state in costante aumento a partire dal 1996 fino al 2004, per poi subire un’inversione di tendenza negli anni successivi con un -5,7% nel 2008 rispetto al 2004. Complessivamente le emissioni energetiche di gas serra nel 2008 sono cresciute del 8,2% rispetto al 1990. Inoltre, sulla base delle quantità di emissioni, l’Italia potrebbe non essere in grado di rispettare l’obiettivo di riduzione fissato per l’Italia dal Protocollo di Kyoto e dal burden sharing interno dell’Unione Europea (una riduzione del 6,5% tra il 2008 e il 2012, con riferimento ai livelli…