Author: Ramon Casas

0000000000820378

AUTHOR

Ramon Casas

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Mukaiyama-type, eight-membered ring closure: Access to a tricyclic system related to taxanes

1998

Abstract Addition of Me2CuLi, with in situ trapping by TMSCl, to Hagemann's ester derivative 13, furnished silyl enol ether 14. Mukaiyama-type cyclization of the latter compound gave the tricyclic derivative 15, structurally related to the taxane core.

chemistry.chemical_classificationchemistry.chemical_compoundChemistryStereochemistryOrganic ChemistryDrug DiscoverySilyl enol etherRing (chemistry)BiochemistryDerivative (chemistry)TricyclicTetrahedron Letters

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