6533b835fe1ef96bd129f3d4
RESEARCH PRODUCT
Mukaiyama-type, eight-membered ring closure: Access to a tricyclic system related to taxanes
Christian CavéChristian CavéJean D'angeloIngrid ValancogneRamon Casassubject
chemistry.chemical_classificationchemistry.chemical_compoundChemistryStereochemistryOrganic ChemistryDrug DiscoverySilyl enol etherRing (chemistry)BiochemistryDerivative (chemistry)Tricyclicdescription
Abstract Addition of Me2CuLi, with in situ trapping by TMSCl, to Hagemann's ester derivative 13, furnished silyl enol ether 14. Mukaiyama-type cyclization of the latter compound gave the tricyclic derivative 15, structurally related to the taxane core.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-05-01 | Tetrahedron Letters |