0000000000131546

AUTHOR

Jean D'angelo

showing 2 related works from this author

Stereocontrolled approach to quinuclidine derivatives

1998

Abstract Asymmetric Michael-type cyclization of chiral enamino ester (S)-7 furnished the quinuclidinone derivative (3R, 4S)-5, with a high degree of stereoselectivity.

chemistry.chemical_compoundDegree (graph theory)Derivative (finance)ChemistryStereochemistryOrganic ChemistryDrug DiscoveryStereoselectivityBiochemistryQuinuclidineTetrahedron Letters
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Mukaiyama-type, eight-membered ring closure: Access to a tricyclic system related to taxanes

1998

Abstract Addition of Me2CuLi, with in situ trapping by TMSCl, to Hagemann's ester derivative 13, furnished silyl enol ether 14. Mukaiyama-type cyclization of the latter compound gave the tricyclic derivative 15, structurally related to the taxane core.

chemistry.chemical_classificationchemistry.chemical_compoundChemistryStereochemistryOrganic ChemistryDrug DiscoverySilyl enol etherRing (chemistry)BiochemistryDerivative (chemistry)TricyclicTetrahedron Letters
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