0000000000821531

AUTHOR

J. Mayer

showing 4 related works from this author

Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA a…

2019

Although additional cytogenetic abnormalities (ACA) do not affect the prognosis of patients with t(15;17) acute promyelocytic leukemia (APL), the role of a complex karyotype (CK) is yet to be clarified. We aimed to investigate the relationship of CK with relapse incidence in 1559 consecutive APL patients enrolled in three consecutive trials. Treatment consisted of AIDA induction followed by risk-adapted consolidation. A CK (CK) was defined as the presence of ≥2 ACA, and a very CK (CK+) as ≥3 ACA. Eighty-nine patients (8%) had a CK, of whom 41 (4%) had CK+. The 5-year cumulative incidence of relapse (CIR) in patients with CK was 18%, and 12% in those with <2 ACA (p=.09). Among patients wi…

MaleCancer Researchcomplex karyotypeANTHRACYCLINE MONOCHEMOTHERAPYmedicine.medical_treatmentAbnormal KaryotypechemotherapyGastroenterologyLeukocyte Count0302 clinical medicineLeukemia Promyelocytic AcuteRecurrenceAcute promyelocytic leukemiaAntineoplastic Combined Chemotherapy ProtocolsPROGNOSTIC-SIGNIFICANCECumulative incidenceATRAChildIn Situ Hybridization FluorescenceAged 80 and overrelapsePETHEMAIncidence (epidemiology)ADDITIONAL CHROMOSOME-ABNORMALITIESAge FactorsHematologyMiddle AgedPrognosisARSENIC TRIOXIDEFLT3 MUTATIONSLeukemiaTreatment OutcomeOncologyChild Preschool030220 oncology & carcinogenesisCytogenetic AnalysisFemaleAdultAcute promyelocytic leukemiamedicine.medical_specialtyCYTOGENETIC CHANGESAdolescentYoung Adult03 medical and health sciencesInternal medicineStatistical significanceComplex KaryotypemedicineHumansClinical significanceAgedCONSOLIDATION THERAPYChromosome AberrationsChemotherapybusiness.industrymedicine.diseaseRISK-ADAPTED TREATMENTTRANS-RETINOIC ACIDATRA Acute promyelocytic leukemia chemotherapy complex karyotype prognostic relapsebusinessprognostic030215 immunologyLeukemia & Lymphoma
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Unseeded Elastomeric Single Leaflets Retain Function and Remodel After Implant In Ovine Pulmonary Outflow Tract

2013

Current materials for heart valve replacement and repair are limited by the inability to grow or remodel. Tissue engineered valves offer the potential to overcome these disadvantages by creating living structures, but is limited by the availability of biocompatible scaffold materials with desirable biomechanical properties. We assessed the in vivo performance of a novel scaffold poly(carbonate urethane) urea (PCUU), fabricated by electrospinning and implanted in the pulmonary outflow tract of sheep. PCUU was electrospun into elastomeric sheets of thickness ranging from 120-180 μm. Using cardiopulmonary bypass we replaced the native anterior pulmonary leaflet with an acellular PCUU leaflet. …

Pulmonary valve Tissue engineering Valvular heart disease Molecular Remodeling.
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Heat-capacity anomaly due to spin reorientation and thermodynamic functions of ErFeO3 and TmFeO3

2001

Abstract Heat capacities of orthoferrites, ErFeO 3 and TmFeO 3 , have been measured below room temperature by adiabatic calorimetry. A broad but definite anomaly due to the spin reorientation phenomenon was successfully detected in the expected temperature range (ca. 90 K). The results are compared with a vast anomaly reported for YbFeO 3 . The temperature dependence of the electric quadrupole splitting of the Fe nuclear levels was determined by Mossbauer spectroscopy through the spin reorientation. A heat capacity anomaly centered at 3.60 K due to the magnetic ordering of Er 3+ ions was clearly detected. Some Schottky anomalies were resolved and energy splittings involved were roughly esti…

Materials scienceCondensed matter physicsMössbauer spectroscopyCalorimetryQuadrupole splittingAtmospheric temperature rangeAnomaly (physics)Condensed Matter PhysicsAdiabatic processSpin (physics)Heat capacityElectronic Optical and Magnetic MaterialsJournal of Magnetism and Magnetic Materials
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Search for quark contact interactions in dijet angular distributions in pp collisions at s=7 TeV measured with the ATLAS detector

2011

Dijet angular distributions from the first LHC pp collisions at center-of-mass energy sqrt(s) = 7 TeV have been measured with the ATLAS detector. The dataset used for this analysis represents an integrated luminosity of 3.1 pb-1. Dijet $\chi$ distributions and centrality ratios have been measured up to dijet masses of 2.8 TeV, and found to be in good agreement with Standard Model predictions. Analysis of the $\chi$ distributions excludes quark contact interactions with a compositeness scale $\Lambda$ below 3.4 TeV, at 95% confidence level, significantly exceeding previous limits.

QuarkPhysicsNuclear and High Energy PhysicsParticle physicsLuminosity (scattering theory)Large Hadron ColliderScale (ratio)010308 nuclear & particles physicsAtlas detectorAstrophysics::High Energy Astrophysical PhenomenaHigh Energy Physics::Phenomenology7. Clean energy01 natural sciencesStandard ModelNuclear physicsmedicine.anatomical_structureAtlas (anatomy)0103 physical sciencesmedicineHigh Energy Physics::Experiment010306 general physicsPhysics Letters B
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