Porous biomaterials and scaffolds for tissue engineering
In the present article, an overview of the definition of tissue engineering and scaffold requirements is reported. In particular, scaffold porosity and its relevance for several tissue target regeneration is highlighted. Different scaffold fabrication techniques are reported and explained in details, highlighting advantages and disadvantages for all of these techniques, regarding the specific final applications.
In vitro degradation and bioactivity of composite poly-l-lactic (PLLA)/bioactive glass (BG) scaffolds: comparison of 45S5 and 1393BG compositions
The objective of this study was to compare the effect of two bioglass (BG) compositions 45S5 and 1393 in poly-l-lactic composite scaffolds in terms of morphology, mechanical properties, biodegradation, water uptake and bioactivity. The scaffolds were produced via thermally induced phase separation starting from a ternary polymer solution (polymer/solvent/non-solvent). Furthermore, different BG to polymer ratios have been selected (1, 2.5, 5% wt/wt) to evaluate the effect of the amount of filler on the composite structure. Results show that the addition of 1393BG does not affect the scaffold morphology, whereas the 45S5BG at the highest amount tends to appreciably modify the scaffold archite…