0000000000822735

AUTHOR

Fernando Fariñas

showing 2 related works from this author

Immunometabolism Modulation in Therapy.

2021

The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of pathways related to tumor development can open up new therapeutic intervention opportunities, such as metabolic regulation applied to immunotherapy. This review outlines the role of various oncometabolites and immunometabolites, such as TCA intermediates, in shaping pro/anti-inflammatory activity of immune cells such as MDSCs, T lymphocytes, …

0301 basic medicineMetabolic stateQH301-705.5medicine.medical_treatmentMetabolic reprogrammingMedicine (miscellaneous)Tumor cellsReviewBiologyGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineImmune systemimmunometabolites; metabolic reprogramming; oncometabolites; regulatory balancemedicinemetabolic reprogrammingCancer biologyregulatory balanceBiology (General)Ensure healthy lives and promote well-being for all at all agesCancerImmunotherapymedicine.diseaseimmunometabolitesoncometabolites030104 developmental biologyMetabolic regulation030220 oncology & carcinogenesisNeuroscience
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Metabolic classification and intervention opportunities for tumor energy dysfunction

2021

A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms. Cancer is now considered a heterogeneous ecosystem, formed by tumor cells and the microenvironment, which is molecularly, phenotypically, and metabolically reprogrammable. A wealth of evidence confirms metabolic reprogramming activity as the minimum common denominator of cancer, grouping together a wide variety of aberrations that can affect any of the different metabolic pathways involved in cell physiology. This forms the basis for a new proposed classification of cancer accordin…

0301 basic medicineEndocrinology Diabetes and MetabolismMetabolic reprogrammingReviewBiologyBioinformaticsBiochemistryMicrobiology03 medical and health sciences0302 clinical medicinetumor reprogrammingmedicinetumor microenvironmentMolecular BiologyTumor ecosystemTumor reprogrammingTumor microenvironmentCancerCommon denominatorMetabolismHypoxia (medical)medicine.diseaseQR1-502Metabolic pathway030104 developmental biologyCell metabolismTumor microenvironment030220 oncology & carcinogenesistumor ecosystemmedicine.symptom
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