6533b835fe1ef96bd129f742
RESEARCH PRODUCT
Immunometabolism Modulation in Therapy.
Amparo López-carrascoTomás ÁLvaro NaranjoIsaac Vieco-martíAntonio J. VillatoroSergio AbanadesSantos MañesRosa NogueraLuis De La Cruz-merinoSabina SanegreFernando FariñasEzequiel Monferrersubject
0301 basic medicineMetabolic stateQH301-705.5medicine.medical_treatmentMetabolic reprogrammingMedicine (miscellaneous)Tumor cellsReviewBiologyGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineImmune systemimmunometabolites; metabolic reprogramming; oncometabolites; regulatory balancemedicinemetabolic reprogrammingCancer biologyregulatory balanceBiology (General)Ensure healthy lives and promote well-being for all at all agesCancerImmunotherapymedicine.diseaseimmunometabolitesoncometabolites030104 developmental biologyMetabolic regulation030220 oncology & carcinogenesisNeurosciencedescription
The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of pathways related to tumor development can open up new therapeutic intervention opportunities, such as metabolic regulation applied to immunotherapy. This review outlines the role of various oncometabolites and immunometabolites, such as TCA intermediates, in shaping pro/anti-inflammatory activity of immune cells such as MDSCs, T lymphocytes, TAMs and DCs in cancer. We also discuss the extraordinary plasticity of the immune response and its implication in immunotherapy efficacy, and highlight different therapeutic intervention possibilities based on controlling the balanced systems of specific metabolites with antagonistic functions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-07-09 |