0000000000828158
AUTHOR
Ignazio Riili
showing 4 related works from this author
Surgical palliation for malignant obstructive jaundice:our experience
2006
BACKGROUND): The prognosis of patlcnts with priimsrv bilian and pancreatic mahgnances is poor. At the time of diagnosis, approxiiuately $0°’ of paticnts are found to hae an nnresectable tumour, because of local sprcad or metastatic disease. ‘lherefore, most patients wilI undergo j,alhative treatment, which is amcd at the ilnprovetnent ofthe quality oflife and the prevention of the svmptoms. This study report personal experience and deserihes the bcst evidence in recent literature. PA’IIENThAND METIIO1)S: 20 paticnts with malignant obstructie jaundice for unresectable hihar or pancreatic neoplasm underwent palliative surgieal treatment. Ofthesc patients, 11 was nien and 9 women, with a mean …
The role of sentinel lymph-node biopsy (SLNB) in the treatment of breast cancer.
2006
Sentinel lymph-node biopsy is an innovative method for axillary staging in breast cancer patients, based on the concept that information about the status of the entire lymphatic drainage from a tumour site could be obtained by identification and sampling of a "sentinel node". The aim of the study was to evaluate the impact of sentinel lymph-node biopsy in the management of patients with early invasive breast carcinoma. Three hundred and forty-one patients with primary invasive breast carcinoma measuring less than 2 cm (less than 3 cm from January 2001) and clinically negative axillary nodes were recruited into the study. Sentinel lymph-nodes were positive for metastases in 108/341 cases (31…
New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations
2018
Matrix metalloproteases (MMPS) are a family of well-known enzymes which operate prevalently in the extracellular domain, where they fulfil the function of remodeling the extracellular matrix. Within the about 26 family members, encoded by 24 genes in humans, MMP-2 and MMP-9, have been regarded as the primary responsibility for the basement membrane and pericellular ECM rearrangement. In cases of infiltrating carcinomas, which arise from the epithelial tissues of a gland or of an internal organ, a marked alteration of the expression and the activity levels of both MMPs is known to occur. Present investigation represents the continuation and upgrading of our previous studies, now focusing on …
Differential occurrence of S100A7 in breast cancer tissues: A proteomic-based investigation
2012
Purpose The present study reports for the first time a large-scale proteomic screening of the occurrence, subcellular localization and relative quantification of the S100A7 protein among a group of 100 patients, clinically grouped for the diagnosis of infiltrating ductal carcinoma (IDC). Experimental design To this purpose, the methods of differential proteomics, Western blotting, and immunohistochemistry were used. Results The identity of two isoforms of the protein was assessed by mass spectrometry and immunologically confirmed. Moreover, we proved by immunocytochemical applications the exclusive localization of the protein within the neoplastic cells. The correlation of S100A7 expression…