0000000000848596

AUTHOR

Jess E. Sussmann

showing 2 related works from this author

Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

2019

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) a…

PharmacologyAdultMaleBipolar DisorderCorrectionBrainDiagnostic markersBiologyTranslational researchmedicine.diseaseMega-White MatterCorpus CallosumWhite matterPsychiatry and Mental healthmedicine.anatomical_structureDiffusion Tensor ImagingNeural PathwaysmedicineHumansFemaleBipolar disorderClinical psychologyNeuropsychopharmacology
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Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

2019

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD);\ud however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical\ud heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with\ud BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered\ud individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean\ud fractional anisotropy (FA) from 43 regions of i…

Pathologymedicine.medical_specialtyCorpus callosumArticleWhite matter03 medical and health sciences0302 clinical medicineFractional anisotropyCingulum (brain)MedicineManic-depressive illnessBipolar disorderPharmacologyTrastorn bipolarbusiness.industryDiagnostic markersAnisotropiaTranslational researchmedicine.disease030227 psychiatryPsychiatry and Mental healthmedicine.anatomical_structureMeta-analysisAnisotropybusiness030217 neurology & neurosurgeryDiffusion MRITractography
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