6533b858fe1ef96bd12b6d7d
RESEARCH PRODUCT
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
Jess E. SussmannUnn K. HaukvikUnn K. HaukvikMichèle WessaPedro G.p. RosaPhilip B. MitchellPhilip B. MitchellTrine Vik LagerbergTrine Vik LagerbergHenk TemminghHenk TemminghChristoph AbéTomas HajekEdith Pomarol-clotetSonya FoleyChantal HenryNeda JahanshadMartin AldaFranz HozerHarald KugelMircea PolosanJacques StoutErick Jorge Canales-rodríguezPauline FavrePauline FavrePeter R. SchofieldPeter R. SchofieldJosselin HouenouMichael DeppeGloria RobertsGloria RobertsHeather C. WhalleyTiffany M. Chaim-avanciniNorma VerdoliniClara AllozaClara AllozaOle A. AndreassenOle A. AndreassenMarcus V. ZanettiSalvador SarróMauricio H. SerpaMelissa PaulingMelissa PaulingJonathan ReppleR. SalvadorGeraldo F. BusattoAnnerine RoosChristopher R.k. ChingChristopher R.k. ChingDominik GrotegerdMarion LeboyerMarion LeboyerUdo DannlowskiLisa T. EylerLisa T. EylerXavier CaserasFrancesco BenedettiKang SimKang SimSilvia Alonso-lanaSamuel SarrazinJulia LinkeJulia LinkeBernhard T. BauneBernhard T. BauneJean-françois ManginAndrew M. McintoshAndrew M. McintoshMar Fatjó-vilasEdouard DuchesnayVieta EduardDan J. SteinStephen M. LawriePaul M. ThompsonFleur M. HowellsElisa M T Mellonisubject
Pathologymedicine.medical_specialtyCorpus callosumArticleWhite matter03 medical and health sciences0302 clinical medicineFractional anisotropyCingulum (brain)MedicineManic-depressive illnessBipolar disorderPharmacologyTrastorn bipolarbusiness.industryDiagnostic markersAnisotropiaTranslational researchmedicine.disease030227 psychiatryPsychiatry and Mental healthmedicine.anatomical_structureMeta-analysisAnisotropybusiness030217 neurology & neurosurgeryDiffusion MRITractographydescription
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD);\ud however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical\ud heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with\ud BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered\ud individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean\ud fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and\ud meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD\ud compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R2 = 0.041, Pcorr < 0.001) and\ud cingulum (right: R2 = 0.041, left: R2 = 0.040, Pcorr < 0.001). Lithium medication, later onset and short disease duration were related to\ud higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities\ud in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD.\ud These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-08-01 |