0000000000848626
AUTHOR
Hiroshi Ishikawa
showing 2 related works from this author
The Impact of Small Extracellular Vesicles on Lymphoblast Trafficking across the Blood-Cerebrospinal Fluid Barrier In Vitro.
2020
Central nervous System (CNS) disease in pediatric acute lymphoblastic leukemia (ALL) is a major concern, but still, cellular mechanisms of CNS infiltration are elusive. The choroid plexus (CP) is a potential entry site, and, to some extent, invasion resembles CNS homing of lymphocytes during healthy state. Given exosomes may precondition target tissue, the present work aims to investigate if leukemia-derived exosomes contribute to a permissive phenotype of the blood-cerebrospinal fluid barrier (BCSFB). Leukemia-derived exosomes were isolated by ultracentrifugation from the cell lines SD-1, Nalm-6, and P12-Ichikawa (P12). Adhesion and uptake to CP epithelial cells and the significance on sub…
Guest Editors' Introduction: Multimedia Metadata and Semantic Management
2009
This special issue assesses the current status and technologies and describes major challenges and proper solutions for effective multimedia production and management related to evolving Semantic Web strategies. The included articles, which cover different facets of the semantic management of multimedia and multimedia metadata from retrieval and processing to consumption and presentation, represent a step forward in research targeted at improving aspects of the semantic metadata life cycle.