0000000000849108

AUTHOR

Giorgio Russo 1

showing 4 related works from this author

A smart and operator independent system to delineate tumours in Positron Emission Tomography scans

2018

Abstract Positron Emission Tomography (PET) imaging has an enormous potential to improve radiation therapy treatment planning offering complementary functional information with respect to other anatomical imaging approaches. The aim of this study is to develop an operator independent, reliable, and clinically feasible system for biological tumour volume delineation from PET images. Under this design hypothesis, we combine several known approaches in an original way to deploy a system with a high level of automation. The proposed system automatically identifies the optimal region of interest around the tumour and performs a slice-by-slice marching local active contour segmentation. It automa…

Lung NeoplasmsComputer sciencemedicine.medical_treatmentPET imagingPattern Recognition Automated030218 nuclear medicine & medical imaging0302 clinical medicineNeoplasmsImage Processing Computer-AssistedSegmentationDiagnosis Computer-AssistedNeoplasm MetastasisRadiation treatment planningSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniObserver VariationActive contour modelmedicine.diagnostic_testBrain NeoplasmsPhantoms ImagingComputer Science ApplicationsHead and Neck NeoplasmsPositron emission tomography030220 oncology & carcinogenesis18F-fluoro-2-deoxy-d-glucoseAlgorithms18F-fluoro-2-deoxy-d-glucose and 11C-labeled methionine PET imagingSimilarity (geometry)Health InformaticsSensitivity and SpecificityNOActive contour algorithm03 medical and health sciencesFluorodeoxyglucose F18Predictive Value of TestsRegion of interestmedicineHumansFalse Positive ReactionsRetrospective Studies18F-fluoro-2-deoxy-d-glucose 11C-labeled methionine PET imaging Active contour algorithm Biological target volume Cancer segmentationbusiness.industryRadiotherapy Planning Computer-Assisted11C-labeled methionineReproducibility of ResultsPattern recognitionGold standard (test)Cancer segmentationRadiation therapyBiological target volumePositron-Emission TomographyArtificial intelligenceTomography X-Ray ComputedbusinessSoftwareComputers in Biology and Medicine
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High-Intensity Focused Ultrasound- and Radiation Therapy-Induced Immuno-modulation: Comparison and Potential Opportunities

2017

In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity. Radiation therapy (RT) is the main treatment modality used for many types of tu…

0301 basic medicinePathologymedicine.medical_specialtyRadiology Nuclear Medicine and ImagingAcoustics and Ultrasonicsmedicine.medical_treatmentBiophysicsImmunomodulation03 medical and health sciences0302 clinical medicineImmune systemNeoplasmsmedicineBystander effectHumansCancerChemotherapyRadiological and Ultrasound Technologybusiness.industryCancermedicine.diseasePrimary tumorThermal ablationHigh-intensity focused ultrasoundRadiation therapyImmuno-therapyRadiation therapyTumor vaccine030104 developmental biologyBiophysicHigh-intensity focused ultrasound030220 oncology & carcinogenesisCancer cellCancer researchHigh-Intensity Focused Ultrasound AblationAnti-tumor immunitybusinessAnti-tumor immunity; Cancer; High-intensity focused ultrasound; Immuno-therapy; Radiation therapy; Thermal ablation; Tumor vaccine
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An enhanced random walk algorithm for delineation of head and neck cancers in PET studies

2017

An algorithm for delineating complex head and neck cancers in positron emission tomography (PET) images is presented in this article. An enhanced random walk (RW) algorithm with automatic seed detection is proposed and used to make the segmentation process feasible in the event of inhomogeneous lesions with bifurcations. In addition, an adaptive probability threshold and a k-means based clustering technique have been integrated in the proposed enhanced RW algorithm. The new threshold is capable of following the intensity changes between adjacent slices along the whole cancer volume, leading to an operator-independent algorithm. Validation experiments were first conducted on phantom studies:…

Similarity (geometry)Computer sciencePET imagingBiomedical EngineeringRandom walk030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicinemedicineImage Processing Computer-AssistedHumansSegmentationComputer visionCluster analysisEvent (probability theory)Settore ING-INF/05 - Sistemi Di Elaborazione Delle Informazionimedicine.diagnostic_testbusiness.industryPhantoms ImagingBiological target volume; Head and neck cancer segmentation; PET imaging; Random walksComputer Science ApplicationPattern recognitionRandom walkComputer Science ApplicationsBiological target volumeHausdorff distancePositron emission tomographyHead and Neck Neoplasms030220 oncology & carcinogenesisPositron-Emission TomographyArtificial intelligenceHead and neck cancer segmentationComputer Vision and Pattern RecognitionbusinessAlgorithmsBiological target volume Head and neck cancer segmentation PET imaging Random walks Algorithms Head and Neck Neoplasms Humans Image Processing Computer-Assisted Phantoms Imaging Positron-Emission TomographyVolume (compression)
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Proton-irradiated breast cells: molecular points of view

2019

Abstract Breast cancer (BC) is the most common cancer in women, highly heterogeneous at both the clinical and molecular level. Radiation therapy (RT) represents an efficient modality to treat localized tumor in BC care, although the choice of a unique treatment plan for all BC patients, including RT, may not be the best option. Technological advances in RT are evolving with the use of charged particle beams (i.e. protons) which, due to a more localized delivery of the radiation dose, reduce the dose administered to the heart compared with conventional RT. However, few data regarding proton-induced molecular changes are currently available. The aim of this study was to investigate and descri…

breast cancer cDNA microarray gene signature proton therapy radiation Breast Breast Neoplasms Cell Line Tumor DNA Complementary Dose-Response Relationship Radiation Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Inflammation MCF-7 Cells Oligonucleotide Array Sequence Analysis Phenotype Proton Therapy Radiation Tolerance Radiotherapy ProtonsDNA ComplementaryHealth Toxicology and Mutagenesismedicine.medical_treatmentBreast NeoplasmsCell fate determinationRadiation Tolerancegene signature03 medical and health sciences0302 clinical medicineBreast cancerbreast cancerCell Line TumorRegular Papermedicineproton therapyHumansRadiology Nuclear Medicine and imagingBreastClonogenic assayBiologyProton therapyOligonucleotide Array Sequence Analysis030304 developmental biologyInflammationcDNA microarray0303 health sciencesRadiotherapyChemistryGene Expression ProfilingBreast cancer; radiation; cDNA microarray; gene signature; proton therapyCancerDose-Response Relationship RadiationGene signaturemedicine.diseaseGene Expression Regulation NeoplasticGene expression profilingRadiation therapyradiationPhenotype030220 oncology & carcinogenesisMCF-7 CellsCancer researchFemaleProtons
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