Author: Vd Longo

0000000000850064

AUTHOR

Vd Longo

A radical signal activates the epigenetic regulation of longevity

Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.

research product

The yeast chronological lifespan to study aging and disease

The yeast chronological lifespan to study aging and disease. In S.N. Witt (a cura di), yeast as a model for human disease.

research product

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
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  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
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  - PE2_16Non-linear physics
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  - PE1_10ODE and dynamical systems
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  - PE1_11Theoretical aspects of partial differential equations
  - PE1_13Probability
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  - PE1_4 Algebraic and complex geometry
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  - PE1_2Algebra
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  - PE11_2Engineering of metals and alloys
  - PE11_1Engineering of biomaterials, biomimetic, bioinspired and bio-enabled materials
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  - PE11_8Engineering of alternative established or emergent materials
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  - PE11_10Soft materials engineering, e.g. gels, foams, colloids
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  - PE11_12Semi-conducting and magnetic materials engineering
  - PE11_13Metamaterials engineering
  - PE11_14Computational methods for materials engineering
LSLife Sciences
- LS1Molecules of Life: Biological Mechanisms, Structures and Functions
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  - LS1_12Protein design
  - LS1_13Early translational research and drug design
  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
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  - LS1_9Molecular mechanisms of signalling processes
  - LS1_7Molecular biophysics, biomechanics, bioenergetics
- LS2Integrative Biology: from Genes and Genomes to Systems
  - LS2_1Genetics
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  - LS4_1Organ and tissue physiology and pathophysiology
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  - LS4_2Comparative physiology
  - LS4_5Non-hormonal mechanisms of inter-organ and tissue communication
  - LS4_6Microbiome and host physiology
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- LS3Cell Biology, Development, Stem Cells and Regeneration
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- LS5Neuroscience and Disorders of the Nervous System
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  - LS5_7Sensory systems, sensation and perception, including pain
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SHSocial Sciences and Humanities
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