0000000000852073
AUTHOR
Maciej Kamaszewski
An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Abstract Background Neoplasms are common across the animal kingdom and seem to be a feature plesiomorphic for metazoans, related with an increase in somatic complexity. The fossil record of cancer complements our knowledge of the origin of neoplasms and vulnerability of various vertebrate taxa. Here, we document the first undoubted record of primary malignant bone tumour in a Mesozoic non-amniote. The diagnosed osteosarcoma developed in the vertebral intercentrum of a temnospondyl amphibian, Metoposaurus krasiejowensis from the Krasiejów locality, southern Poland. Results A wide array of data collected from gross anatomy, histology, and microstructure of the affected intercentrum reveals th…
Additional file 7 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Additional file 7. Close-ups of osteocytes lacunae in the neoplasm-affected part of vertebral intercentrum showing their subspherical shapes.
Additional file 6 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Additional file 6. Photoscan of ground section of normal, non-altered anterodorsal vertebral intercentrum of Metoposaurus krasiejowensis, for comparative purposes, specimen number UOPB 00118 [1].
Additional file 1 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Additional file 1. 3D model of ZPAL Ab III/2467.
Additional file 3 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Additional file 3. 3D model of pathologically-altered intercentrum, virtually extracted from microtomographic scans.
Additional file 4 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Additional file 4. 3D model of bone outgrowth, virtually extracted from microtomographic scans.
Additional file 5 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Additional file 5. 3D model of ZPAL Ab III/2467 with marked scanning planes.
Additional file 2 of An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?
Additional file 2. Juxtaposition of the 3D model of ZPAL Ab III/2467 and 3D volumetric reconstructions of the remaining normal part of the pathologically-altered intercentrum and bone outgrowth (tumour).