Author: Juliusz Pryjma

0000000000855663

AUTHOR

Juliusz Pryjma

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Effect of Soluble Interleukin-6 Receptor on Interleukin-6 Synthesis in Human Skin Fibroblasts

1996

Abstract In this study the ability of soluble interleukin-6 receptor (sIL-6R) to stimulate interleukin-6 (IL-6) synthesis in human fibroblasts is described. It was found that sIL-6R, in combination with endogenous or exogenous IL-6, markedly upregulated IL-6 synthesis. These data suggest that increased IL-6 production after stimulation by either interleukin-1 or tumor necrosis factor-α would result in complex formation with sIL-6R, rapid uptake, and further synthesis of this cytokine. Furthermore, it would explain the decrease in sIL-6R plasma levels observed in patients suffering from sepsis.

medicine.medical_specialtymedicine.medical_treatmentBiophysicsGene ExpressionHuman skinStimulationEndogenyBiochemistryDownregulation and upregulationAntigens CDInternal medicinemedicineHumansInterleukin 6ReceptorMolecular BiologyCells CulturedSkinbiologyInterleukin-6Receptors InterleukinCell BiologyFibroblastsReceptors Interleukin-6Recombinant ProteinsKineticsCytokineEndocrinologybiology.proteinTumor necrosis factor alphaBiochemical and Biophysical Research Communications

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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SHSocial Sciences and Humanities
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